Evidence map›Paper›PMID 38407952›Full record

ArticleeLife2024

RBP-J regulates homeostasis and function of circulating Ly6C

Tiantian Kou, Lan Kang, Bin Zhang, Jiaqi Li, Baohong Zhao, Wenwen Zeng, Xiaoyu Hu

Open access · goldAbstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Tiantian Kou *Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China.
Lan Kang *Institute for Immunology and School of Medicine, Tsinghua University, Beijing, China.ORCID https://orcid.org/0000-0002-8643-9174
Bin ZhangInstitute for Immunology and School of Medicine, Tsinghua University, Beijing, China.
Jiaqi LiInstitute for Immunology and School of Medicine, Tsinghua University, Beijing, China.
Baohong ZhaoArthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery, New York, United States.ORCID https://orcid.org/0000-0002-1286-0919
Wenwen ZengInstitute for Immunology and School of Medicine, Tsinghua University, Beijing, China.ORCID https://orcid.org/0000-0001-8544-3318
Xiaoyu HuInstitute for Immunology and School of Medicine, Tsinghua University, Beijing, China.ORCID https://orcid.org/0000-0002-4289-6998
King Center · USTsinghua University · CNHospital for Special Surgery · US

Funding

Ministry of Science and Technology of the People's Republic of China 2020YFA0509100National Natural Science Foundation of China 31821003National Natural Science Foundation of China 31991174National Natural Science Foundation of China 32030037National Natural Science Foundation of China 82150105
6 · The paper itself

Abstract

Notch-RBP-J signaling plays an essential role in the maintenance of myeloid homeostasis. However, its role in monocyte cell fate decisions is not fully understood. Here, we showed that conditional deletion of transcription factor RBP-J in myeloid cells resulted in marked accumulation of blood Ly6C

Indexed as

MonocytesMyeloid CellsBone Marrow TransplantationHomeostasisMacrophagesReceptors, ChemokineReceptors, ChemokineCCR2immunologyinflammationlung interstitial macrophageLy6Clo monocytemouseRBP-J

Identifiers

PMID38407952
PMCPMC10942619
OpenAlexW4379798917

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.