Body mass index modifies the effect of urinary protein-to-creatinine ratio on chronic kidney disease progression.

Jiancheng Wang, Qiwei Fan, Ying Hu, Lingyan Zhu, Jixiong Xu

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In one paragraph

Article in International urology and nephrology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jiancheng WangDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, People's Republic of China. Jason095@ncu.edu.cn.ORCID http://orcid.org/0009-0009-5278-6432

Qiwei FanDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, People's Republic of China.

Ying HuDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, People's Republic of China.

Lingyan ZhuDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, People's Republic of China.

Jixiong XuDepartment of Endocrinology and Metabolism, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, No. 17, Yongwaizheng Street, Nanchang, 330006, Jiangxi, People's Republic of China. Jixiong.Xu@ncu.edu.cn.

Nanchang University · CN

Funding

Innovative Research Group Project of the National Natural Science Foundation of China No. 82160139Science and Technology Project of the Education Department of Jiangxi Province No. GJJ190059

6 · The paper itself

Abstract

backgroundThis study aimed to determine the association between the urinary protein-to-creatinine ratio (UPCR) and chronic kidney disease (CKD) progression in a cohort study, and to determine whether body mass index (BMI) modifies this association.

methodsThe study population consisted of 856 hypertensive patients with CKD stages 2-5, enrolled between 2010 and 2011 in Japan. Generalized linear models with a logit link were used to evaluate the independent and combined effects of the UPCR and BMI on CKD progression

resultsDuring a median follow-up of 25 months, 242 patients developed CKD progression during follow-up. A notably higher risk of CKD progression was found in participants in tertiles 2 [odds ratio (OR): 5.46, 95% confidence interval (95% CI): 2.49-11.99] and 3 (OR 27.74, 95% CI 12.34-62.38) comparing with tertiles 1 for UPCR levels. Moreover, an interaction was found between UPCR and BMI on CKD progression (P for interaction = 0.006). Participants in both the highest tertile of UPCR and overweight (UPCR ≥ 248.9 mg/mmol and BMI ≥ 25 kg/m

Indexed as

Body Mass IndexCreatinineDisease ProgressionProteinuriaRenal Insufficiency, ChronicAgedCohort StudiesFemaleHumansMaleMiddle AgedCreatinineBMIChronic kidney diseaseHypertensionProteinuriaUPCR

Identifiers

PMID38407753

DOI10.1007/s11255-024-03984-z

OpenAlexW4392157465

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.