Evidence map›Paper›PMID 38407533›Full record

ArticleEuropean journal of neurology2024

Frequency and outcomes of gastrostomy insertion in a longitudinal cohort study of atypical parkinsonism.

Christopher Kobylecki, Viorica Chelban, Yee Yen Goh, Emilia Michou, Riona Fumi, Marte Theilmann Jensen, Rahema Mohammad, Alyssa Costantini, Nirosen Vijiaratnam, Samantha Pavey and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Prognostic factors of survival in corticobasal syndrome and corticobasal degeneration: A scoping review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 10 institutions in 3 countries.

Christopher KobyleckiDivision of Neuroscience, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK.ORCID 0000-0002-7797-0756
Viorica ChelbanDepartment of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0002-5817-6290
Yee Yen GohDepartment of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, UK.
Emilia MichouDivision of Diabetes, Endocrinology and Gastroenterology, University of Manchester, Manchester, UK.ORCID 0000-0002-7245-0882
Riona FumiDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Marte Theilmann JensenDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Rahema MohammadDepartment of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, UK.
Alyssa CostantiniDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Nirosen VijiaratnamDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Samantha PaveyMultiple System Atrophy Trust, London, UK.
Nicola PaveseClinical Ageing Research Unit, Newcastle University, Newcastle, UK.ORCID 0000-0002-6801-6194
P Nigel LeighDepartment of Neuroscience, Brighton and Sussex Medical School, Brighton, UK.
James B RoweDepartment of Clinical Neurosciences, Cambridge Centre for Parkinson-Plus, Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
Michele T HuDivision of Neurology, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Alistair ChurchDepartment of Neurology, Royal Gwent Hospital, Newport, UK.
Huw R MorrisDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Henry HouldenDepartment of Neuromuscular Diseases, Queen Square Institute of Neurology, University College London, London, UK.
National Hospital for Neurology and Neurosurgery · GBBrighton and Sussex Medical School · GBManchester Academic Health Science Centre · GBMultiple System Atrophy Trust · GBNicolae Testemițanu State University of Medicine and Pharmacy · MDNIHR Newcastle Biomedical Research Centre · GBNuffield Orthopaedic Centre · GBRoyal Gwent Hospital · GBUniversity of Cambridge · GBUniversity of Patras · GR

Funding

Medical Research Council MR/Y008219/1
6 · The paper itself

Abstract

backgroundMultiple system atrophy (MSA), progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) show a high prevalence and rapid progression of dysphagia, which is associated with reduced survival. Despite this, the evidence base for gastrostomy is poor, and the optimal frequency and outcomes of this intervention are not known. We aimed to characterise the prevalence and outcomes of gastrostomy in patients with these three atypical parkinsonian disorders.

methodWe analysed data from the natural history and longitudinal cohorts of the PROSPECT-M-UK study with up to 60 months of follow-up from baseline. Survival post-gastrostomy was analysed using Kaplan-Meier survival curves.

resultsIn a total of 339 patients (mean age at symptom onset 63.3 years, mean symptom duration at baseline 4.6 years), dysphagia was present in >50% across all disease groups at baseline and showed rapid progression during follow-up. Gastrostomy was recorded as recommended in 44 (13%) and performed in 21 (6.2%; MSA 7, PSP 11, CBS 3) of the total study population. Median survival post-gastrostomy was 24 months compared with 12 months where gastrostomy was recommended but not done (p = 0.008). However, this was not significant when correcting for age and duration of symptoms at the time of procedure or recommendation.

conclusionsGastrostomy was performed relatively infrequently in this cohort despite the high prevalence of dysphagia. Survival post-gastrostomy was longer than previously reported, but further data on other outcomes and clinician and patient perspectives would help to guide use of this intervention in MSA, PSP and CBS.

Indexed as

Deglutition DisordersGastrostomyMultiple System AtrophyParkinsonian DisordersSupranuclear Palsy, ProgressiveAgedCohort StudiesDisease ProgressionFemaleHumansLongitudinal StudiesMaleMiddle AgedTreatment Outcomedysphagiagastrostomymultiple system atrophyparkinsonismprogressive supranuclear palsy

Identifiers

PMID38407533
PMCPMC11235814
OpenAlexW4392165841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.