Evidence map›Paper›PMID 38406782›Full record

ArticleJournal of medicine and life2023

The association between serum ferritin and bilirubin with glycemic control among patients with type 2 diabetes mellitus.

Reem Al Argan, Dania Alkhafaji, Abdulmohsen Al Elq, Waleed Albaker, Yasir Elamin, Abrar Alwaheed, Mohammad Zeeshan, Zainab AlElq, Malak Alkhalifa, Rana Al Mansour and 6 more

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Article in Journal of medicine and life, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Reem Al ArganDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Dania AlkhafajiDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Abdulmohsen Al ElqDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Waleed AlbakerDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Yasir ElaminDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Abrar AlwaheedDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Mohammad ZeeshanDepartment of Medical Education, College of Medicine, Imam Abdulrahman Bin Faisal University, Khobar, Saudi Arabia.
Zainab AlElqDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Malak AlkhalifaDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Rana Al MansourDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Shada AlghamdiDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Abdulelah Al GhamdiDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Fatema IsmaeelDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Adnan AlmarzouqDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Fatma ZainuddinDepartment of Medical Allied Services, King Fahad Hospital of the University, Khobar, Saudi Arabia.
Reem AlSulaimanDepartment of Internal Medicine, College of Medicine, Imam Abdulrahman Bin Faisal University, King Fahad Hospital of the University, Khobar, Saudi Arabia.
King Fahd Hospital of the University · SAImam Abdulrahman Bin Faisal University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous evidence has shown an association between serum ferritin and bilirubin levels in the development of type 2 diabetes mellitus (T2DM) and glycemic control. However, the evidence is scarce in Saudi Arabia. In this study, we aimed to evaluate the association between serum ferritin and bilirubin levels with glycemic control in patients with T2DM. This was a cross-sectional study that involved 153 patients with T2DM recruited from outpatient diabetes clinics. Participants were categorized into two groups: well-controlled and uncontrolled T2DM, based on their glycemic status. We focused on comparing the iron profile and bilirubin levels between these two groups and examining the influence of antidiabetic medications on these parameters. A total of 153 patients with T2DM were included (58.2% women and 41.8% men). In both univariate and multivariate analyses, ferritin levels did not have a statistically significant association with glycemic control. However, patients with well-controlled T2DM had a significantly higher median level of total bilirubin and direct bilirubin than those with uncontrolled T2DM. Only direct bilirubin showed a statistically significant association with FBG less than 130 mg/dl and HbA1c level less than 7.0%. Ferritin level was not associated with glycemic control in patients with T2DM. On the other hand, direct bilirubin level was an independent predictor of better glycemic control. Monitoring direct bilirubin levels could aid in predicting glycemic control in T2DM and could be a potential target for developing antidiabetic medications.

Indexed as

Diabetes Mellitus, Type 2BilirubinBlood GlucoseCross-Sectional StudiesFemaleFerritinsGlycemic ControlHumansHypoglycemic AgentsMaleBilirubinBlood GlucoseFerritinsHypoglycemic AgentsALP - Alkaline phosphataseALT - Alanine transaminaseAST - Aspartate aminotransferaseBUN - Blood urea nitrogenCO2 - Carbon dioxidedirect bilirubinDM - Diabetes mellitusDPP-4 - Dipeptidyl peptidase-4eGFR - Estimated glomerular filtration ratefasting blood glucoseFBG - Fasting blood glucoseferritinGGTP - Gamma-glutamyl transpeptidaseGLP-1 - Glucagon-like peptide 1glycemic controlHbA1cHbA1c - Glycosylated hemoglobinIQR - Interquartile rangeK - PotassiumMCHC - Mean corpuscular hemoglobin concentrationMCH - Mean corpuscular hemoglobinMCV - Mean corpuscular volumeNa - SodiumSGLT2 - Sodium glucose cotransporter 2T2DM - Type 2 diabetes mellitusTIBC - Total iron-binding capacitytotal bilirubinType 2 diabetes mellitusWBC - White blood cells

Identifiers

PMID38406782
PMCPMC10893562
OpenAlexW4394759447

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.