Evidence map›Paper›PMID 38406595›Full record

ReviewOncology letters2024

Applications of single‑cell omics and spatial transcriptomics technologies in gastric cancer (Review).

Liping Ren, Danni Huang, Hongjiang Liu, Lin Ning, Peiling Cai, Xiaolong Yu, Yang Zhang, Nanchao Luo, Hao Lin, Jinsong Su and 1 more

Abstract readReview
In one paragraph

Review in Oncology letters, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Liping RenSchool of Healthcare Technology, Chengdu Neusoft University, Chengdu, Sichuan 611844, P.R. China.
Danni HuangDepartment of Radiology, Central South University Xiangya School of Medicine Affiliated Haikou People's Hospital, Haikou, Hainan 570208, P.R. China.
Hongjiang LiuSchool of Computer Science and Technology, Aba Teachers College, Aba, Sichuan 624099, P.R. China.
Lin NingSchool of Healthcare Technology, Chengdu Neusoft University, Chengdu, Sichuan 611844, P.R. China.
Peiling CaiSchool of Basic Medical Sciences, Chengdu University, Chengdu, Sichuan 610106, P.R. China.
Xiaolong YuHainan Yazhou Bay Seed Laboratory, Sanya Nanfan Research Institute, Material Science and Engineering Institute of Hainan University, Sanya, Hainan 572025, P.R. China.
Yang ZhangInnovative Institute of Chinese Medicine and Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, P.R. China.
Nanchao LuoSchool of Computer Science and Technology, Aba Teachers College, Aba, Sichuan 624099, P.R. China.
Hao LinCenter for Informational Biology, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, P.R. China.
Jinsong SuResearch Institute of Integrated Traditional Chinese Medicine and Western Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan 611137, P.R. China.
Yinghui ZhangSchool of Healthcare Technology, Chengdu Neusoft University, Chengdu, Sichuan 611844, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Gastric cancer (GC) is a prominent contributor to global cancer-related mortalities, and a deeper understanding of its molecular characteristics and tumor heterogeneity is required. Single-cell omics and spatial transcriptomics (ST) technologies have revolutionized cancer research by enabling the exploration of cellular heterogeneity and molecular landscapes at the single-cell level. In the present review, an overview of the advancements in single-cell omics and ST technologies and their applications in GC research is provided. Firstly, multiple single-cell omics and ST methods are discussed, highlighting their ability to offer unique insights into gene expression, genetic alterations, epigenomic modifications, protein expression patterns and cellular location in tissues. Furthermore, a summary is provided of key findings from previous research on single-cell omics and ST methods used in GC, which have provided valuable insights into genetic alterations, tumor diagnosis and prognosis, tumor microenvironment analysis, and treatment response. In summary, the application of single-cell omics and ST technologies has revealed the levels of cellular heterogeneity and the molecular characteristics of GC, and holds promise for improving diagnostics, personalized treatments and patient outcomes in GC.

Indexed as

cellular heterogeneitygastric cancersingle-cell omicsspatial transcriptomicstumor microenvironment

Identifiers

PMID38406595
PMCPMC10885005

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.