Evidence map›Paper›PMID 38406538›Full record

ArticleEJHaem2024

Circulating tumor DNA for monitoring classic Hodgkin lymphoma patients: Correlation with FDG-PET/CT.

Sara Fernández, Laura Cereceda, Eva Díaz, Sasha Figueroa, Laura Reguera, Victoria Menéndez, José L Solórzano, Carlos Montalbán, Mónica Estévez, Juan F García

Erratum issuedAbstract read
In one paragraph

Article in EJHaem, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Sara FernándezTranslational Research, Fundación MD Anderson International España S.L. Madrid Madrid Spain.
Laura CerecedaTranslational Research, Fundación MD Anderson International España S.L. Madrid Madrid Spain.
Eva DíazTranslational Research, Fundación MD Anderson International España S.L. Madrid Madrid Spain.
Sasha FigueroaTranslational Research, Fundación MD Anderson International España S.L. Madrid Madrid Spain.
Laura RegueraNuclear Medicine Department MD Anderson Cancer Center Madrid Madrid Spain.
Victoria MenéndezTranslational Research, Fundación MD Anderson International España S.L. Madrid Madrid Spain.
José L SolórzanoPathology Department MD Anderson Cancer Center Madrid Madrid Spain.
Carlos MontalbánHematology Department MD Anderson Cancer Center Madrid Madrid Spain.
Mónica EstévezHematology Department MD Anderson Cancer Center Madrid Madrid Spain.
Juan F GarcíaTranslational Research, Fundación MD Anderson International España S.L. Madrid Madrid Spain.ORCID https://orcid.org/0000-0001-6974-0806

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The value of circulating tumor DNA (ctDNA) as a biomarker of disease activity in classic Hodgkin lymphoma (cHL) patients has not yet been well established. By profiling primary tumors and ctDNA, we identified common variants between primary tumors and longitudinal plasma samples in most of the cases, confirming high spatial and temporal heterogeneity. Although ctDNA analyses mirrored HRS cell genetics overall, the prevalence of variants shows that none of them can be used as a single biomarker. Conversely, the estimation of hGE/mL, based on measures of total ctDNA, reflects disease activity and is almost perfectly correlated with standard parameters such as PET/CT that are associated with refractoriness.

Indexed as

Hodgkins lymphomalymphoid malignanciesminimal residual disease

Identifiers

PMID38406538
PMCPMC10887323

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.