ReviewMedical cannabis and cannabinoids
Cannabis and Anxiety: A Critical Review.
Review in Medical cannabis and cannabinoids. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Harm perceptions of smoking versus vaping cannabis and correlates: national surveys of youth and young adults in England, Canada, and the United States.Addictive behaviors · 2026Article
- Trends before and after legalization and COVID-19 on cannabis use among gay, bisexual, and other men who have sex with men in Montreal, Toronto, and Vancouver, Canada: A prospective cohort study.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Examining the transdiagnostic role of coping motives and experiential avoidance in the relationship between generalized anxiety disorder and addictive behaviours.Journal of behavioral addictions · 2026Article
- Beyond the Diagnostic Binary: A Translational Use of the Research Domain Criteria to Improve the Measurement of Anxiety in the Context of Cannabis Use.Healthcare (Basel, Switzerland) · 2026Article
- Mystery shopper assessments of cannabis retailer practices and regulatory compliance in five U.S. states, 2025.Drug and alcohol dependence · 2026Article
- Article
- NfL and GFAP quantification and associations with mental health in recreational cannabis users-Results from the Swiss study on recreational cannabis access via pharmacies.Molecular neurobiology · 2026Article
- Associations of cannabis use, other substances, and lifestyle choices on anxiety in medical cannabis patients across 45 days.Scientific reports · 2026Article
- Canadian real-world evidence: observational 24-week outcomes for health care practitioner authorized cannabis.Canadian journal of pain = Revue canadienne de la douleur · 2026Article
- Cannabis use among primary care patients with depression and anxiety disorders: cross-sectional analysis in a large health system in Los Angeles, CA.Journal of cannabis research · 2025Article
- Content Analysis of Cannabis Discourses on Twitter/X in the U.S.AJPM focus · 2025Article
- Frequency of cannabis use and symptoms of anxiety and depression: a cross-sectional analysis of the Colorado cannabis users health cohort.Journal of cannabis research · 2025Article
- Will you precrastinate? Sensitivity to potential performance costs and effort in chronic cannabis users and non-users.Psychological research · 2025Article
- Cannabis, cannabinoids and health: a review of evidence on risks and medical benefits.European archives of psychiatry and clinical neuroscience · 2025Review
- The Effects of Indirect and Direct Modulation of Endocannabinoid System Function on Anxiety-Related Behavior in Mice Assessed in the Elevated Plus Maze Test.Molecules (Basel, Switzerland) · 2025Article
- How Biodegradable Polymers Can be Effective Drug Delivery Systems for Cannabinoids? Prospectives and Challenges.International journal of nanomedicine · 2024Review
- Are Metacognitive Beliefs and Cognitive Flexibility Associated With Cannabis Use Disorder In Adolescents? A Case-Control Study.Clinical psychology & psychotherapyArticle
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Cannabis has been reported to have both anxiogenic and anxiolytic effects. Habitual cannabis use has been associated with anxiety disorders (AD). The causal pathways and mechanisms underlying the association between cannabis use (CU)/cannabis use disorder (CUD) and anxiety remain unclear. We examined the literature via a systematic review to investigate the link between cannabis and anxiety. The hypotheses studied include causality, the common factor theory, and the self-medication hypothesis. Methods: Critical systematic review of published literature examining the relationship of CU/CUD to AD or state-anxiety, including case reports, literature reviews, observational studies, and preclinical and clinical studies. A systematic MEDline search was conducted of terms including: [anxiety], [anxiogenic], [anxiolytic], [PTSD], [OCD], [GAD], [cannabis], [marijuana], [tetrahydrocannabinol], [THC]. Results: While several case-control and cohort studies have reported no correlation between CU/CUD and AD or state anxiety ( Conclusion: The association between cannabis and anxiety is best explained by anxiety predisposing individuals toward CU as a method of self-medication. A causal relationship in which CU causes AD incidence is less likely despite multiple longitudinal studies suggesting so.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.