ArticleACS nanoscience Au2024
Label-Free Tracking of Proteins through Plasmon-Enhanced Interference.
Article in ACS nanoscience Au, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Rapid trapping and label-free optical characterization of single nanoscale extracellular vesicles and nanoparticles in solution.Light, science & applications · 2026Article
- Label-free mass and size characterization of few-kDa biomolecules by hierarchical vision transformer augmented nanofluidic scattering microscopy.Nature communications · 2026Article
- AI-assisted label-free single-particle analysis of milk-derived extracellular vesicles enabled by nanotweezers.Npj biosensing · 2026Article
- Enhanced Interferometric Imaging by Rotating Coherent Scattering Microscopy.ACS photonics · 2025Article
- Accessible Double Nanohole Raman Tweezer Analysis of Single Nanoparticles.The journal of physical chemistry. C, Nanomaterials and interfaces · 2024Article
- Structural Flexibility and Disassembly Kinetics of Single Ferritin Molecules Using Optical Nanotweezers.ACS nano · 2024Article
- Energy landscape of conformational changes for a single unmodified protein.Npj biosensing · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Single unmodified biomolecules in solution can be observed and characterized by interferometric imaging approaches; however, Rayleigh scattering limits this to larger proteins (typically >30 kDa). We observe real-time image tracking of unmodified proteins down to 14 kDa using interference imaging enhanced by surface plasmons launched at an aperture in a metal film. The larger proteins show slower diffusion, quantified by tracking. When the diffusing protein is finally trapped by the nanoaperture, we perform complementary power spectral density and noise amplitude analysis, which gives information about the protein. This approach allows for rapid protein characterization with minimal sample preparation and opens the door to characterizing protein interactions in real time.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.