Evidence map›Paper›PMID 38406178›Full record

ArticleNeurophotonics2024

FiPhA: an open-source platform for fiber photometry analysis.

Matthew F Bridge, Leslie R Wilson, Sambit Panda, Korey D Stevanovic, Ayland C Letsinger, Sandra McBride, Jesse D Cushman

Abstract read
In one paragraph

Article in Neurophotonics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Matthew F BridgeSocial & Scientific Systems, Inc., a DLH Holdings Corp. Company, Durham, North Carolina, United States.
Leslie R WilsonNational Institute of Environmental Health Sciences, National Institutes of Health, Neurobiology Laboratory, Division of Intramural Research, Durham, North Carolina, United States.ORCID https://orcid.org/0000-0001-9535-7544
Sambit PandaNational Institute of Environmental Health Sciences, National Institutes of Health, Neurobiology Laboratory, Division of Intramural Research, Durham, North Carolina, United States.ORCID https://orcid.org/0000-0001-8455-4243
Korey D StevanovicNational Institute of Environmental Health Sciences, National Institutes of Health, Neurobiology Laboratory, Division of Intramural Research, Durham, North Carolina, United States.ORCID https://orcid.org/0000-0003-4453-1631
Ayland C LetsingerNational Institute of Environmental Health Sciences, National Institutes of Health, Neurobiology Laboratory, Division of Intramural Research, Durham, North Carolina, United States.ORCID https://orcid.org/0000-0001-7331-3647
Sandra McBrideSocial & Scientific Systems, Inc., a DLH Holdings Corp. Company, Durham, North Carolina, United States.ORCID https://orcid.org/0000-0003-3730-9864
Jesse D CushmanNational Institute of Environmental Health Sciences, National Institutes of Health, Neurobiology Laboratory, Division of Intramural Research, Durham, North Carolina, United States.ORCID https://orcid.org/0000-0003-1311-0076

Funding

Neurobehavioral Core LaboratoryZICES103330 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI CUSHMAN, JESSE · 2018 to 2025
$13.3M
Intramural NIH HHS ZIC ES103330
6 · The paper itself

Abstract

Significance: Fiber photometry (FP) is a widely used technique in modern behavioral neuroscience, employing genetically encoded fluorescent sensors to monitor neural activity and neurotransmitter release in awake-behaving animals. However, analyzing photometry data can be both laborious and time-consuming. Aim: We propose the fiber photometry analysis (FiPhA) app, which is a general-purpose FP analysis application. The goal is to develop a pipeline suitable for a wide range of photometry approaches, including spectrally resolved, camera-based, and lock-in demodulation. Approach: FiPhA was developed using the R Shiny framework and offers interactive visualization, quality control, and batch processing functionalities in a user-friendly interface. Results: This application simplifies and streamlines the analysis process, thereby reducing labor and time requirements. It offers interactive visualizations, event-triggered average processing, powerful tools for filtering behavioral events, and quality control features. Conclusions: FiPhA is a valuable tool for behavioral neuroscientists working with discrete, event-based FP data. It addresses the challenges associated with analyzing and investigating such data, offering a robust and user-friendly solution without the complexity of having to hand-design custom analysis pipelines. This application thus helps standardize an approach to FP analysis.

Indexed as

calcium imagingevent processingfiber photometryR, Shiny

Identifiers

PMID38406178
PMCPMC10885510

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.