Evidence map›Paper›PMID 38405988›Full record

ArticlebioRxiv : the preprint server for biology2024

Complementary Cytoskeletal Feedback Loops Control Signal Transduction Excitability and Cell Polarity.

Jonathan Kuhn, Parijat Banerjee, Andrew Haye, Douglas N Robinson, Pablo A Iglesias, Peter N Devreotes

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jonathan KuhnDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD.ORCID 0000-0003-2355-8982
Parijat BanerjeeDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD.
Andrew HayeDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD.
Douglas N RobinsonDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD.
Pablo A IglesiasDepartment of Electrical and Computer Engineering, Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-0840-155X
Peter N DevreotesDepartment of Cell Biology, Johns Hopkins School of Medicine, Baltimore, MD.ORCID 0000-0002-3260-1455
Johns Hopkins University · US

Funding

Excitable Networks in Directed Cell MigrationR35GM118177 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Peter N Devreotes · 2016 to 2026
$12.1M
The Biochemical Basis for the Mechanics of CytokinesisR01GM066817 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ROBINSON, DOUGLAS N · 2003 to 2025
$7.3M
Molecular Mechanisms of Cytoskeletal Mechanosensory SystemsR01GM149073 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Pablo A. Iglesias, DOUGLAS N ROBINSON · 2023 to 2026
$2.6M
Zeiss LSM780 Confocal Microscope for a Core FacilityS10OD016374 · OD · JOHNS HOPKINS UNIVERSITY · PI KUO, SCOT CHARLES · 2013 to 2013
$584k
NIGMS NIH HHS R01 GM066817NIGMS NIH HHS R01 GM149073NIGMS NIH HHS R35 GM118177NIH HHS S10 OD016374
6 · The paper itself

Abstract

To move through complex environments, cells must constantly integrate chemical and mechanical cues. Signaling networks, such as those comprising Ras and PI3K, transmit chemical cues to the cytoskeleton, but the cytoskeleton must also relay mechanical information back to those signaling systems. Using novel synthetic tools to acutely control specific elements of the cytoskeleton in

Identifiers

PMID38405988
PMCPMC10888828
OpenAlexW4391771653

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.