Evidence map›Paper›PMID 38405931›Full record

ArticlebioRxiv : the preprint server for biology2025

iSCORE-PD: an isogenic stem cell collection to research Parkinson's Disease.

Oriol Busquets, Hanqin Li, Khaja Mohieddin Syed, Pilar Alvarez Jerez, Jesse Dunnack, Riana Lo Bu, Yogendra Verma, Gabriella R Pangilinan, Annika Martin, Jannes Straub and 17 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 3 countries.

Oriol BusquetsDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.ORCID 0000-0002-1372-9699
Hanqin LiAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0001-7995-1084
Khaja Mohieddin SyedAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0002-7682-7608
Pilar Alvarez JerezCenter for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0002-5812-1898
Jesse DunnackAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0002-0387-0090
Riana Lo BuDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.ORCID 0000-0002-1732-5878
Yogendra VermaAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0003-3380-6089
Gabriella R PangilinanAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0003-2662-7883
Annika MartinDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0006-3369-1495
Jannes StraubAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0002-7178-1663
YuXin DuAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0001-5212-5372
Vivien M SimonDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0001-1976-0937
Steven PoserDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.ORCID 0000-0003-4868-1389
Zipporiah BushAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0002-6304-9579
Jessica DiazDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.ORCID 0000-0001-7165-6590
Atehsa SahagunAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0001-7521-3279
Jianpu GaoDepartment of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA.ORCID 0009-0007-4535-6587
Samantha HongCenter for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0009-0001-8968-6461
Dena G HernandezLaboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0002-0188-9927
Kristin S LevineCenter for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0002-5702-0980
Ezgi O BoothAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0001-9213-8426
Marco BlanchetteLiftOff Biosolution. 813 Isbel Ct, Santa Cruz 95060, USA.ORCID 0009-0005-5592-7166
Helen S BateupAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0002-0135-0972
Donald C RioAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0002-4775-3515
Cornelis BlauwendraatCenter for Alzheimer's and Related Dementias, National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0001-9358-8111
Dirk HockemeyerAligning Science Across Parkinson's (ASAP) Collaborative Research Network, Chevy Chase, MD, 20815, USA.ORCID 0000-0002-5598-5092
Frank SoldnerDominick P. Purpura Department of Neuroscience, Albert Einstein College of Medicine, Rose F. Kennedy Center, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA.ORCID 0000-0002-7102-8655
Research Network (United States) · USAlbert Einstein College of Medicine · USNational Institutes of Health · USUniversity of California, Berkeley · USInnovative Genomics Institute · USChan Zuckerberg Initiative (United States) · USComputer Science Laboratory of Lille · FR

Funding

WORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2M
Biology and Biotechnology of Cell and Gene TherapyT32GM139780 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Amy Elizabeth Herr, Dirk Hockemeyer · 2021 to 2026
$2.4M
Zeiss Confocal Microscope with Airyscan for Einstein Neural Cell Engineering and Imaging CoreS10OD025295 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI DOBRENIS, KOSTANTIN · 2019 to 2019
$523k
NCI NIH HHS P30 CA013330NIGMS NIH HHS T32 GM139780NIH HHS S10 OD025295
6 · The paper itself

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder caused by complex genetic and environmental factors. Genome-edited human pluripotent stem cells (hPSCs) offer a unique experimental platform to advance our understanding of PD etiology by enabling the generation of disease-relevant cell types carrying patient mutations along with isogenic control cells. To facilitate this approach, we generated a collection of 65 human stem cell lines genetically engineered to harbor high risk or causal variants in genes associated with PD (

Identifiers

PMID38405931
PMCPMC10888955
OpenAlexW4391820161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.