Evidence map›Paper›PMID 38405920›Full record

ArticleResearch square2024

Skeletal abnormalities caused by a Connexin43

Yasuyuki Fujii, Iichiro Okabe, Ayano Hatori, Shyam Kishor Sah, Jitendra Kanaujiya, Melanie Fisher, Rachael Norris, Mark Terasaki, Ernst J Reichenberger, I-Ping Chen

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Yasuyuki FujiiDepartment of Endodontology, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.
Iichiro OkabeDepartment of Endodontology, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.
Ayano HatoriDepartment of Endodontology, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.
Shyam Kishor SahDepartment of Endodontology, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.
Jitendra KanaujiyaDepartment of Cell Biology, University of Connecticut Health, Farmington, CT, United States.
Melanie FisherDepartment of Cell Biology, University of Connecticut Health, Farmington, CT, United States.
Rachael NorrisDepartment of Cell Biology, University of Connecticut Health, Farmington, CT, United States.
Mark TerasakiDepartment of Cell Biology, University of Connecticut Health, Farmington, CT, United States.
Ernst J ReichenbergerCenter for Regenerative Medicine and Skeletal Development, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.
I-Ping ChenDepartment of Endodontology, School of Dental Medicine, University of Connecticut Health, Farmington, CT, United States.ORCID 0000-0002-7349-3091
UConn Health · US

Funding

Pathogenic Mechanisms of Craniometaphyseal DysplasiaR01DE025664 · NIDCR · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI I-Ping Chen · 2016 to 2026
$4.5M
NIDCR NIH HHS R01 DE025664
6 · The paper itself

Abstract

Craniometaphyseal dysplasia (CMD), a rare craniotubular disorder, occurs in an autosomal dominant (AD) or autosomal recessive (AR) form. CMD is characterized by hyperostosis of craniofacial bones and flaring metaphyses of long bones. Many patients with CMD suffer from neurological symptoms. To date, the pathogenesis of CMD is not fully understood. Treatment is limited to decompression surgery. Here, we report a knock in (KI) mouse model for AR CMD carrying a R239Q mutation in CX43.

Indexed as

Bone histomorphometryBone μCTGenetic animal modelsOsteoclastsOsteocytes

Identifiers

PMID38405920
PMCPMC10889043
OpenAlexW4391572718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.