Evidence map›Paper›PMID 38405907›Full record

ArticlebioRxiv : the preprint server for biology2024

High-throughput investigation of genetic design constraints in domesticated Influenza A Virus for transient gene delivery.

Adam Sychla, Christopher S Stach, Shanley N Roach, Amanda N Hayward, Ryan A Langlois, Michael J Smanski

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Adam SychlaDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN 55108.
Christopher S StachDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN 55108.
Shanley N RoachDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN 55108.
Amanda N HaywardDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN 55108.
Ryan A LangloisDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN 55108.
Michael J SmanskiDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Saint Paul, MN 55108.
University of Minnesota · US

Funding

TRAINING FOR FUTURE BIOTECHNOLOGY DEVELOPMENTT32GM008347 · NIGMS · UNIVERSITY OF MINNESOTA TWIN CITIES · PI SCHMIDT-DANNERT, CLAUDIA · 1990 to 2021
$11.0M
NIGMS NIH HHS T32 GM008347
6 · The paper itself

Abstract

Replication-incompetent single cycle infectious Influenza A Virus (sciIAV) has demonstrated utility as a research and vaccination platform. Protein-based therapeutics are increasingly attractive due to their high selectivity and potent efficacy but still suffer from low bioavailability and high manufacturing cost. Transient RNA-mediated delivery is a safe alternative that allows for expression of protein-based therapeutics within the target cells or tissues but is limited by delivery efficiency. Here, we develop recombinant sciIAV as a platform for transient gene delivery

Indexed as

Antimicrobial peptidesProtein manufacturingrIAVTransient gene delivery

Identifiers

PMID38405907
PMCPMC10888799
OpenAlexW4391838569

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.