Evidence map›Paper›PMID 38405884›Full record

ArticlebioRxiv : the preprint server for biology2024

REV1 Coordinates a Multi-Faceted Tolerance Response to DNA Alkylation Damage and Prevents Chromosome Shattering in

Varandt Khodaverdian, Tokio Sano, Lara Maggs, Gina Tomarchio, Ana Dias, Connor Clairmont, Mai Tran, Mitch McVey

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Varandt KhodaverdianDepartment of Biology, Tufts University, Medford, MA 02155.
Tokio SanoDepartment of Biology, Tufts University, Medford, MA 02155.
Lara MaggsDepartment of Biology, Tufts University, Medford, MA 02155.
Gina TomarchioCurrent address: Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY.ORCID 0000-0002-3797-2319
Ana DiasDepartment of Biology, Tufts University, Medford, MA 02155.ORCID 0009-0000-4447-4652
Connor ClairmontDepartment of Biology, Tufts University, Medford, MA 02155.
Mai TranDepartment of Biology, Tufts University, Medford, MA 02155.
Mitch McVeyDepartment of Biology, Tufts University, Medford, MA 02155.ORCID 0000-0001-8883-0188
Tufts University · USMemorial Sloan Kettering Cancer Center · US

Funding

DNA damage tolerance pathway choice in DrosophilaR01GM125827 · NIGMS · TUFTS UNIVERSITY MEDFORD · PI MCVEY, MITCH · 2020 to 2023
$1.4M
NIGMS NIH HHS R01 GM125827
6 · The paper itself

Abstract

When replication forks encounter damaged DNA, cells utilize DNA damage tolerance mechanisms to allow replication to proceed. These include translesion synthesis at the fork, postreplication gap filling, and template switching via fork reversal or homologous recombination. The extent to which these different damage tolerance mechanisms are utilized depends on cell, tissue, and developmental context-specific cues, the last two of which are poorly understood. To address this gap, we have investigated damage tolerance responses following alkylation damage in

Indexed as

abasic siteDNA replicationdouble-strand breakfork regressionmutagenesis

Identifiers

PMID38405884
PMCPMC10888836
OpenAlexW4391819231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.