Evidence map›Paper›PMID 38405837›Full record

ArticleResearch square2024

Metformin reduces the clonal fitness of

Mohsen Hosseini, Veronique Voisin, Ali Chegini, Angelica Varesi, Severine Cathelin, Dhanoop Manikoth Ayyathan, Alex C H Liu, Yitong Yang, Vivian Wang, Abdula Maher and 16 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 5 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

26 authors at 8 institutions in 3 countries.

Mohsen HosseiniPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Veronique VoisinDonnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.
Ali CheginiPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Angelica VaresiPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Severine CathelinPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Dhanoop Manikoth AyyathanPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Alex C H LiuPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Yitong YangPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Vivian WangPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Abdula MaherPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Eric GrignanoPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Julie A ReiszDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Angelo D'AlessandroDepartment of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.ORCID 0000-0002-2258-6490
Kira YoungThe Jackson Laboratory, Bar Harbor, ME, USA.
Yiyan WuDepartment of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.
Martina FiumaraSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy.
Samuele FerrariSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy.
Luigi NaldiniSan Raffaele Telethon Institute for Gene Therapy, IRCCS San Raffaele Scientific Institute, Milan, 20132, Italy.ORCID 0000-0002-7835-527X
Federico GaitiPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0000-0001-5111-8816
Shraddha PaiDonnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.
Aaron D SchimmerPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0000-0003-4023-3899
Gary D BaderDonnelly Centre for Cellular and Biomolecular Research, Toronto, Ontario, Canada.
John E DickPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Stephanie Z XiePrincess Margaret Cancer Centre, Toronto, Ontario, Canada.
Jennifer J TrowbridgeThe Jackson Laboratory, Bar Harbor, ME, USA.ORCID 0000-0002-7636-9504
Steven M ChanPrincess Margaret Cancer Centre, Toronto, Ontario, Canada.ORCID 0000-0002-4354-0731
University of Toronto · CAPrincess Margaret Cancer Centre · CAUniversity Health Network · CAJackson Laboratory · USThe San Raffaele Telethon Institute for Gene Therapy · ITOntario Institute for Cancer Research · CAUniversity of Colorado Anschutz Medical Campus · USVita-Salute San Raffaele University · IT

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
NCI NIH HHS P30 CA046592NCI NIH HHS P30 CA046934
6 · The paper itself

Abstract

Clonal hematopoiesis (CH) arises when a hematopoietic stem cell (HSC) acquires a mutation that confers a competitive advantage over wild-type (WT) HSCs, resulting in its clonal expansion. Individuals with CH are at an increased risk of developing hematologic neoplasms and a range of age-related inflammatory illnesses

Identifiers

PMID38405837
PMCPMC10889081
OpenAlexW4391570248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.