Evidence map›Paper›PMID 38405830›Full record

ArticlebioRxiv : the preprint server for biology2024

Multiplex generation and single cell analysis of structural variants in a mammalian genome.

Sudarshan Pinglay, Jean-Benoit Lalanne, Riza M Daza, Jonas Koeppel, Xiaoyi Li, David S Lee, Jay Shendure

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025
    Review
  2. The design and engineering of synthetic genomes.Nature reviews. Genetics · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Sudarshan PinglayDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-8781-1476
Jean-Benoit LalanneDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0001-8753-0669
Riza M DazaDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0003-1635-8675
Jonas KoeppelWellcome Sanger Institute, Hinxton, UK.ORCID 0000-0003-1306-3994
Xiaoyi LiDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
David S LeeDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.
Jay ShendureDepartment of Genome Sciences, University of Washington, Seattle, WA, USA.ORCID 0000-0002-1516-1865
University of Washington · USHoward Hughes Medical Institute · USWellcome Sanger Institute · GB

Funding

Supplement for Center for Synthetic Regulatory Genomics: Building CACNA1C alleles associated with Neuropsychiatric DisordersRM1HG009491 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jef D BOEKE · 2018 to 2026
$20.9M
Versatile, exponentially scalable methods for single cell molecular profilingR01HG010632 · NHGRI · UNIVERSITY OF WASHINGTON · PI Jay Ashok Shendure, Bruce Colston Trapnell · 2019 to 2026
$5.9M
Dissecting the logic of mammalian gene regulation using synthetic biology and single-cell sequencingDP5OD036167 · OD · UNIVERSITY OF WASHINGTON · PI Sudarshan Pinglay · 2023 to 2026
$1.9M
NHGRI NIH HHS R01 HG010632NHGRI NIH HHS RM1 HG009491NIH HHS DP5 OD036167
6 · The paper itself

Abstract

The functional consequences of structural variants (SVs) in mammalian genomes are challenging to study. This is due to several factors, including: 1) their numerical paucity relative to other forms of standing genetic variation such as single nucleotide variants (SNVs) and short insertions or deletions (indels); 2) the fact that a single SV can involve and potentially impact the function of more than one gene and/or

Identifiers

PMID38405830
PMCPMC10888807
OpenAlexW4391138771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.