Evidence map›Paper›PMID 38405802›Full record

ArticleResearch square2024

Partitioned polygenic risk scores identify distinct types of metabolic dysfunction-associated steatotic liver disease.

Stefano Romeo, Oveis Jamialahmadi, Antonio De Vincentis, Federica Tavaglione, Francesco Malvestiti, Ruifang Li-Gao, Rosellina Mancina, Marcus Alvarez, Kyla Gelev, Samantha Maurotti and 6 more

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 5 countries.

Stefano RomeoDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Wallenberg Laboratory, University of Gothenburg.ORCID 0000-0001-9168-4898
Oveis JamialahmadiUniversity of Gothenburg.
Antonio De VincentisOperative Unit of Internal Medicine, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy.
Federica TavaglioneUniversity of Gothenburg.
Francesco MalvestitiUniversity of Milan.ORCID 0000-0002-2430-5883
Ruifang Li-GaoLeiden University Medical Center.
Rosellina MancinaDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, Wallenberg Laboratory, University of Gothenburg.ORCID 0000-0002-1126-3071
Marcus AlvarezUniversity of California, Los Angeles.ORCID 0000-0002-6369-5028
Kyla GelevDavid Geffen School of Medicine at UCLA.
Samantha MaurottiMagna Graecia University.
Umberto Vespasiani-GentilucciFondazione Policlinico Universitario Campus Bio-Medico.
Frits RosendaalLeiden University Medical Center.ORCID 0000-0003-2558-7496
Julia KozlitinaUT Southwestern.ORCID 0000-0001-7720-2290
Päivi PajukantaUniversity of California, Los Angeles.ORCID 0000-0002-6423-8056
François PattouCentre Hospitalier Universitaire de Lille.
Luca ValentiUniversity of Milan.ORCID 0000-0001-8909-0345
University of Milan · ITUniversity of California, Los Angeles · USUniversity of Gothenburg · SECampus Bio Medico University Hospital · ITLeiden University Medical Center · NLMagna Graecia University · IT

Funding

Multimodal omics approach to identify health to cardiometabolic disease transitionsR01HL170604 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Paivi Pajukanta · 2023 to 2026
$2.8M
Methods for Genomic Analysis in Heterogeneous TissuesR01HG010505 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HALPERIN, ERAN · 2019 to 2022
$2.6M
Genetics of adipose cell-type expression and cardiometabolic traitsR01DK132775 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MOHLKE, KAREN L., PAJUKANTA, PAIVI · 2022 to 2025
$2.4M
NHGRI NIH HHS R01 HG010505NHLBI NIH HHS R01 HL170604NIDDK NIH HHS R01 DK132775
6 · The paper itself

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) encompasses an excess of triglycerides in the liver, which can lead to cirrhosis and liver cancer. While there is solid epidemiological evidence of MASLD coexisting with cardiometabolic disease, several leading genetic risk factors for MASLD do not increase the risk of cardiovascular disease, suggesting no causal relationship between MASLD and cardiometabolic derangement. In this work, we leveraged measurements of visceral adiposity and identified 27 novel genetic

Identifiers

PMID38405802
PMCPMC10889080
OpenAlexW4391575665

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.