ArticlemedRxiv : the preprint server for health sciences2025
Adiposity and cancer: systematic review and meta-analysis.
Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 10 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a growing global health challenge and a major cancer risk factor. We conducted a systematic review and meta-analysis of prospective cohorts quantifying associations between body mass index (BMI) and 25 common cancers, searching PubMed, EMBASE and Scopus through April 23rd, 2025. Across 226 articles comprising 1.5 million cancer data points, BMI was positively associated with 19 cancer types and inversely associated with three. We identified positive associations for leukaemia, non-Hodgkin lymphoma, bladder, and glioma-novel findings which were not reported by major consensus reports. Regional differences were observed, including stronger associations for postmenopausal breast and ovarian cancers in East Asia, and weaker associations for gallbladder cancer. BMI and waist circumference showed similar associations with cancer. We also reviewed Mendelian randomisation studies and emerging imaging-based evidence; genetic data largely supported causality, while imaging-data were limited. Our findings underscore the broad and growing impact of obesity on cancer risk.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.