Evidence map›Paper›PMID 38405756›Full record

ArticlebioRxiv : the preprint server for biology2025

Scalable primordial germ cell-like-cell platform for functional genomics identifies epigenetic fertility modifiers.

Liangdao Li, Jingyi Gao, Dain Yi, Alex P Sheft, John C Schimenti, Xinbao Ding

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Liangdao LiCornell University, College of Veterinary Medicine, Department of Biomedical Sciences, Ithaca, NY 14853.
Jingyi GaoCornell University, College of Veterinary Medicine, Department of Biomedical Sciences, Ithaca, NY 14853.
Dain YiCornell University, College of Veterinary Medicine, Department of Biomedical Sciences, Ithaca, NY 14853.
Alex P SheftCornell University, College of Veterinary Medicine, Department of Biomedical Sciences, Ithaca, NY 14853.
John C SchimentiCornell University, College of Veterinary Medicine, Department of Biomedical Sciences, Ithaca, NY 14853.ORCID 0000-0002-7294-1876
Xinbao DingCornell University, College of Veterinary Medicine, Department of Biomedical Sciences, Ithaca, NY 14853.ORCID 0000-0001-5941-4898
Cornell University · US

Funding

Project IIIP50HD096723 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI John C Schimenti · 2019 to 2026
$15.0M
Identification and Functional Validation of Human Infertility AllelesR01HD082568 · NICHD · CORNELL UNIVERSITY · PI SCHIMENTI, JOHN C · 2015 to 2024
$6.0M
NICHD NIH HHS P50 HD096723NICHD NIH HHS R01 HD082568Wellcome Trust CC2024
6 · The paper itself

Abstract

Primordial germ cells (PGCs) are the founder cells of the germline. The ability to generate PGC-like cells (PGCLCs) from pluripotent stem cells has advanced our knowledge of gametogenesis and holds promise for developing infertility treatments. However, generating an ample supply of PGCLCs for demanding applications such as large-scale genetic screens has been a limitation. Here, we demonstrated that simultaneous overexpression of 4 transcriptional factors -

Identifiers

PMID38405756
PMCPMC10888945
OpenAlexW4391880061

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.