Evidence map›Paper›PMID 38405733›Full record

ArticlebioRxiv : the preprint server for biology2024

HIV-1 Mediated Cortical Actin Disruption Mirrors ARP2/3 Defects Found in Primary T Cell Immunodeficiencies.

Jacqueline M Crater, Daniel Dunn, Douglas F Nixon, Robert L Furler O'Brien

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jacqueline M CraterDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.
Daniel DunnDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.
Douglas F NixonDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2801-1786
Robert L Furler O'BrienDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0001-5706-4871

Funding

BELIEVE: Bench to Bed Enhanced Lymphocyte Infusions to Engineer Viral EradicationUM1AI126617 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI JONES, R. BRAD, NIXON, DOUGLAS F · 2016 to 2020
$28.1M
NIAID NIH HHS UM1 AI126617
6 · The paper itself

Abstract

During cell movement, cortical actin balances mechanical and osmotic forces to maintain cell function while providing the scaffold for cell shape. Migrating CD4

Indexed as

ActinARP2/3CD4+ T cellCD4+ T Cell MigrationCell morphologyCytoskeletonHIV-1HIV-1 Nef proteinInborn Errors of ImmunityPrimary ImmunodeficienciesTime-lapse imagingWAVE2Wiskott-Aldrich syndrome

Identifiers

PMID38405733
PMCPMC10888893

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.