Evidence map›Paper›PMID 38405722›Full record

ArticlebioRxiv : the preprint server for biology2024

Psilocybin induces dose-dependent changes in functional network organization in rat cortex.

Brian H Silverstein, Nicholas Kolbman, Amanda Nelson, Tiecheng Liu, Peter Guzzo, Jim Gilligan, UnCheol Lee, George A Mashour, Giancarlo Vanini, Dinesh Pal

Open access · greenAbstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Brian H SilversteinDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Nicholas KolbmanDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Amanda NelsonDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Tiecheng LiuDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Peter GuzzoTryp Therapeutics, Kelowna, British Columbia, V1Y 7T2, Canada.
Jim GilliganTryp Therapeutics, Kelowna, British Columbia, V1Y 7T2, Canada.
UnCheol LeeDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
George A MashourDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Giancarlo VaniniDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
Dinesh PalDepartment of Anesthesiology, University of Michigan, Ann Arbor, Michigan 48109, USA.
University of Michigan · US

Funding

Role of the Prefrontal Cortex in the Control of Arousal StatesR01GM111293 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MASHOUR, GEORGE ALEXANDER, PAL, DINESH · 2015 to 2022
$2.6M
NIGMS NIH HHS R01 GM111293
6 · The paper itself

Abstract

Psilocybin produces an altered state of consciousness in humans and is associated with complex spatiotemporal changes in brain networks. Given the emphasis on rodent models for mechanistic studies, there is a need for characterization of the effect of psilocybin on brain-wide network dynamics. Previous rodent studies of psychedelics, using electroencephalogram, have primarily been done with sparse electrode arrays that offered limited spatial resolution precluding network level analysis, and have been restricted to lower gamma frequencies. Therefore, in the study, we used electroencephalographic recordings from 27 sites (electrodes) across rat cortex (

Indexed as

High gamma oscillationsPhase-Amplitude CouplingPsilocybinPsychedelicRatweighted Phase-Lag Index

Identifiers

PMID38405722
PMCPMC10888735
OpenAlexW4391757540

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.