ArticleACS photonics2024
Label-Free Imaging of DNA Interactions with 2D Materials.
Article in ACS photonics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Chirality Engineering and Properties in Two-Dimensional Layered Materials.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Emission dipole orientation reveals dynamic single-molecule interactions with 2D crystals at solvent interfaces.Nature communications · 2026Article
- Modulation of Single-Molecule Emission at Hexagonal Boron Nitride Surfaces.Nano letters · 2026Article
- Emerging 2D Materials and Their Hybrid Nanostructures for Label-Free Optical Biosensing: Recent Progress and Outlook.Advanced functional materials · 2025Article
- Breaking barriers in the sensitive and accurate mass determination of large DNA plasmids by mass photometry.Molecular therapy. Nucleic acids · 2025Article
- Diffusion of DNA on Atomically Flat 2D Material Surfaces.ACS nano · 2025Article
- Real-time label-free imaging of living crystallization-driven self-assembly.Nature communications · 2025Article
- Quantum sensing with optically accessible spin defects in van der Waals layered materials.Light, science & applications · 2024Article
- Monitoring Electrochemical Dynamics through Single-Molecule Imaging of hBN Surface Emitters in Organic Solvents.ACS nano · 2024Article
- Site-Specific Integration of Hexagonal Boron Nitride Quantum Emitters on 2D DNA Origami Nanopores.Nano letters · 2024Article
- Two-color interferometric scattering (iSCAT) microscopy reveals structural dynamics in discrete plasmonic molecules.Nanoscale · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two-dimensional (2D) materials offer potential as substrates for biosensing devices, as their properties can be engineered to tune interactions between the surface and biomolecules. Yet, not many methods can measure these interactions in a liquid environment without introducing labeling agents such as fluorophores. In this work, we harness interferometric scattering (iSCAT) microscopy, a label-free imaging technique, to investigate the interactions of single molecules of long dsDNA with 2D materials. The millisecond temporal resolution of iSCAT allows us to capture the transient interactions and to observe the dynamics of unlabeled DNA binding to a hexagonal boron nitride (hBN) surface in solution for extended periods (including a fraction of 10%, of trajectories lasting longer than 110 ms). Using a focused ion beam technique to engineer defects, we find that DNA binding affinity is enhanced at defects; when exposed to long lanes, DNA binds preferentially at the lane edges. Overall, we demonstrate that iSCAT imaging is a useful tool to study how biomolecules interact with 2D materials, a key component in engineering future biosensors.
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Registered trials
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