Evidence map›Paper›PMID 38405385›Full record

ArticleSensors & diagnostics2023

Genetically engineered filamentous phage for bacterial detection using magnetic resonance imaging.

Raymond E Borg, Harun F Ozbakir, Binzhi Xu, Eugene Li, Xiwen Fang, Huan Peng, Irene A Chen, Arnab Mukherjee

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sensors & diagnostics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Real-TimeACS biomaterials science & engineering · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Raymond E BorgDepartment of Chemistry, University of California, Santa Barbara, CA 93106, USA.
Harun F OzbakirDepartment of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.
Binzhi XuBiomolecular Science and Engineering, University of California, Santa Barbara, CA 93106, USA.
Eugene LiDepartment of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.
Xiwen FangDepartment of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.
Huan PengDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.
Irene A ChenDepartment of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0001-6040-7927
Arnab MukherjeeDepartment of Chemistry, University of California, Santa Barbara, CA 93106, USA.ORCID 0000-0003-3571-8015
University of California, Santa Barbara · USUniversity of California, Los Angeles · US

Funding

Understanding how bacteriophages affect wound ecologies and developing new tools to harness bacteria-phage interactionsDP2GM123457 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI CHEN, IRENE ANN · 2016 to 2016
$2.3M
Engineering fluorescence and magnetic resonance reporter genes for imaging biological function in hypoxic cells and in vivoR35GM133530 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MUKHERJEE, ARNAB · 2019 to 2023
$1.6M
Phage-inspired engineering and evolutionR35GM148249 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Irene Ann Chen · 2023 to 2026
$1.5M
Engineering a calcium reporter gene for magnetic resonance imaging of neural activityR21EB033989 · NIBIB · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI MUKHERJEE, ARNAB · 2022 to 2023
$425k
NIBIB NIH HHS R21 EB033989NIGMS NIH HHS DP2 GM123457NIGMS NIH HHS R35 GM133530NIGMS NIH HHS R35 GM148249
6 · The paper itself

Abstract

Detecting bacterial cells with high specificity in deep tissues is challenging. Optical probes provide specificity, but are limited by the scattering and absorption of light in biological tissues. Conversely, magnetic resonance imaging (MRI) allows unfettered access to deep tissues, but lacks contrast agents for detecting specific bacterial strains. Here, we introduce a biomolecular platform that combines both capabilities by exploiting the modularity of M13 phage to target bacteria with tunable specificity and allow deep-tissue imaging using

Identifiers

PMID38405385
PMCPMC10888512
OpenAlexW4381687552

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.