ArticleFrontiers in endocrinology2024
Association between circulating immune cells and the risk of prostate cancer: a Mendelian randomization study.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Article
- Causal roles of immune cells and plasma metabolites in esophageal cancer: A Mendelian randomization study with nutritional insights.Asia Pacific journal of clinical nutrition · 2026Article
- Exploratory analysis of immune profiles in 2- to 3-year-old children with growth stunting.Journal of Taibah University Medical Sciences · 2026Article
- Associations between dietary intake and pancreatic disease: a Mendelian randomization study.International journal of surgery (London, England) · 2026Article
- Association of immune cells with the risk of basal cell carcinoma: A bidirectional Mendelian randomized study.Medicine · 2025Article
- The causal relationship between immune cell phenotypes and esophageal cancer development: a bidirectional Mendelian randomization study.Discover oncology · 2025Article
- The mediating factors between systemic lupus erythematosus and prostate cancer risk: a two-step Mendelian randomization and transcriptome analysis.Discover oncology · 2025Article
- Causal association between immune cytokines and psoriasis: A two-way Mendelian randomization study.Medicine · 2025Article
- SPAG11B, a potential biomarker for rheumatoid arthritis: a two-sample bidirectional Mendelian randomization analysis.BMC rheumatology · 2025Article
- Identification of causal plasma metabolite biomarkers for ischemic stroke using Mendelian randomization and mediation analysis.Scientific reports · 2025Article
- Evaluating the impact of gut microbiota, circulating cytokines and plasma metabolites on febrile seizure risk in Mendelian randomization study.Scientific reports · 2025Article
- Deciphering the integrated immunogenomic landscape of colorectal cancer: insights from Mendelian randomization and immune-stratified molecular subtyping.BMC gastroenterology · 2025Article
- Exploring the causal associations of the gut microbiota and plasma metabolites with ovarian cancer: an approach of mendelian randomization analysis combined with network pharmacology and molecular docking.Journal of ovarian research · 2025Article
- Influence of Immune Cells and Circulating Inflammatory Cytokines on Pathological Scars: A Mendelian Randomization Study.Clinical, cosmetic and investigational dermatology · 2025Article
- Causal relationship between cancer and immune cell traits: A two-sample mendelian randomization study.Heliyon · 2024Article
- Effect of the immune cells and plasma metabolites on rheumatoid arthritis: a mediated mendelian randomization study.Frontiers in endocrinology · 2024Article
- Revealing the causal role of immune cells in malignant neoplasms of the head and neck: insights from Mendelian randomization.Frontiers in oncology · 2024Article
- Causality investigation among gut microbiota, immune cells, and prostate diseases: a Mendelian randomization study.Frontiers in microbiology · 2024Article
- The causal relationship between the human gut microbiota and pyogenic arthritis: a Mendelian randomization study.Frontiers in cellular and infection microbiology · 2024Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: There is still limited research on the association between immune cells and the risk of prostate cancer. Further investigations are warranted to comprehend the intricate associations at play. Methods: We used a bidirectional two-sample Mendelian randomization (MR) analysis to investigate the causal relationship between immune cell phenotypes and prostate cancer. The summary data for immune cell phenotypes was derived from a study cohort, including 3,757 individuals from Sardinia with data on 731 immune cell phenotypes. The summary data for prostate cancer were obtained from the UK Biobank database. Sensitivity analyses were conducted, and the combination of MR-Egger and MR-Presso was used to assess horizontal pleiotropy. Cochran's Q test was employed to evaluate heterogeneity, and the results were subjected to FDR correction. Results: Our study identified two immune cell phenotypes significantly associated with the risk of prostate cancer, namely CD25 on naive-mature B cells (OR = 0.998, 95% CI, 0.997-0.999, Conclusion: This study has revealed causal relationships between immune cell phenotypes and prostate cancer, supplying novel insights that might aid in identifying potential therapeutic targets of prostate cancer.
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