Evidence map›Paper›PMID 38405092›Full record

SynthesisThe Pan African medical journal2023

Same-day ART initiation, loss to follow-up and viral load suppression among people living with HIV in low- and middle-income countries: systematic review and meta-analysis.

Hafidha Mhando Bakari, Oluwafemi Alo, Mariam Salim Mbwana, Swalehe Mustafa Salim, Emilie Ludeman, Taylor Lascko, Habib Omari Ramadhani

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in The Pan African medical journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hafidha Mhando BakariPresident's Office Regional Administration and Local Government, Ajira Yako, Tanzania.
Oluwafemi AloCenter for International Health Education and Biosecurity, Maryland Global Initiatives Corporation affiliate of the University of Maryland Baltimore, Abuja, Nigeria.
Mariam Salim MbwanaPrimary Health Care Institute, Iringa, Tanzania.
Swalehe Mustafa SalimCanada Youth Group, Iringa, Tanzania.
Emilie LudemanHealth Services and Human Services Library, University of Maryland Baltimore, Baltimore, United States.
Taylor LasckoCenter for International Health, Education, and Biosecurity, University of Maryland School of Medicine, Baltimore, Maryland, United States.
Habib Omari RamadhaniCenter for International Health, Education, and Biosecurity, University of Maryland School of Medicine, Baltimore, Maryland, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: in 2015, the World Health Organization recommended early antiretroviral therapy (ART) initiation after HIV diagnosis. Mixed results on the effect of same-day ART initiation (SDI) over non-same-day ART initiation (NSDI) on loss to follow-up (LTFU) and viral load suppression (VLS) necessitate further evaluation. Methods: this was a systematic review and meta-analysis of people living with HIV in low- and middle-income countries (LMICs). Multiple databases were searched from January 2016 to December 2022. VLS was defined as HIV RNA <1,000 or <400 cells/ml, depending on the study. Forest plots were used to present the pooled prevalence and 95% confidence intervals (CIs). Heterogeneity was tested by an I Results: sixteen studies (5 clinical trials, 10 cohorts, and 1 cross-sectional) were included in the final analysis. Nine studies with 157,633 people living with HIV were analyzed for LTFU and the pooled prevalence of LTFU was 22.0% (95%CI; 18.5-25.7). The pooled prevalence of VLS was 72.7% (95%CI; 65.4-79.5%). The I Conclusion: nearly two in ten people living with HIV in LMICs who initiated ART were LTFU. SDI was associated with increased risk of LTFU. Efforts to prevent LTFU among those who receive SDI are critical to maximize its potential benefits.

Indexed as

Anti-HIV AgentsHIV InfectionsCross-Sectional StudiesDeveloping CountriesHumansLost to Follow-UpViral LoadAnti-HIV Agentsloss to follow-uplow- and mid-income countriespeople living with HIVSame-day ART initiationviral load suppression

Identifiers

PMID38405092
PMCPMC10891376

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.