Evidence map›Paper›PMID 38404811›Full record

ReviewHeliyon2024

Large-scale mechanism hypothesis and research prospects of cognitive impairment in schizophrenia based on magnetic resonance imaging.

Yue-Wen Gu, Jing-Wen Fan, Shu-Wan Zhao, Xiao-Fan Liu, Hong Yin, Long-Biao Cui

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Yue-Wen GuShaanxi Provincial Key Laboratory of Clinic Genetics, Fourth Military Medical University, Xi'an, China.
Jing-Wen FanShaanxi Provincial Key Laboratory of Clinic Genetics, Fourth Military Medical University, Xi'an, China.
Shu-Wan ZhaoShaanxi Provincial Key Laboratory of Clinic Genetics, Fourth Military Medical University, Xi'an, China.
Xiao-Fan LiuShaanxi Provincial Key Laboratory of Clinic Genetics, Fourth Military Medical University, Xi'an, China.
Hong YinSchizophrenia Imaging Lab, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Long-Biao CuiShaanxi Provincial Key Laboratory of Clinic Genetics, Fourth Military Medical University, Xi'an, China.
Xijing Hospital · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CNXi’an Children’s Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive impairments in schizophrenia are pivotal clinical issues that need to be solved urgently. However, the mechanism remains unknown. It has been suggested that cognitive impairments in schizophrenia are associated with connectome damage, and are especially relevant to the disrupted hub nodes in the frontal and parietal lobes. Activating the dorsolateral prefrontal cortex (DLPFC) via repetitive transcranial magnetic stimulation (rTMS) could result in improved cognition. Based on several previous magnetic resonance imaging (MRI) studies on schizophrenia, we found that the first-episode patients showed connectome damage, as well as abnormal activation and connectivity of the DLPFC and inferior parietal lobule (IPL). Accordingly, we proposed that DLPFC-IPL pathway destruction might mediate connectome damage of cognitive impairments in schizophrenia. In the meantime, with the help of multimodal MRI and noninvasive neuromodulation tool, we may not only validate the hypothesis, but also find IPL as the potential intervention target for cognitive impairments in schizophrenia.

Indexed as

Cognitive impairmentsConnectomeMagnetic resonance imagingSchizophreniaTreatment

Identifiers

PMID38404811
PMCPMC10884805
OpenAlexW4391723137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.