Evidence map›Paper›PMID 38404573›Full record

ArticleFrontiers in immunology2024

TNFα: TNFR1 signaling inhibits maturation and maintains the pro-inflammatory programming of monocyte-derived macrophages in murine chronic granulomatous disease.

Sophie L Gibbings, Kelsey C Haist, Elizabeth F Redente, Peter M Henson, Donna L Bratton

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sophie L GibbingsDepartment of Pediatrics, National Jewish Health, Denver, CO, United States.
Kelsey C HaistDepartment of Pediatrics, National Jewish Health, Denver, CO, United States.
Elizabeth F RedenteDepartment of Pediatrics, National Jewish Health, Denver, CO, United States.
Peter M HensonDepartment of Pediatrics, National Jewish Health, Denver, CO, United States.
Donna L BrattonDepartment of Pediatrics, National Jewish Health, Denver, CO, United States.
University of Colorado Denver · USNational Jewish Health · US

Funding

Neutrophil Nox2 controls mononuclear cell functions in inflammation; role in CGDR01AI141389 · NIAID · NATIONAL JEWISH HEALTH · PI BRATTON, DONNA L, HENSON, PETER M · 2018 to 2022
$3.1M
Roles for interstitial and airspace macrophages in resolution of pulmonary inflammationR01HL149741 · NHLBI · NATIONAL JEWISH HEALTH · PI HENSON, PETER M, REDENTE, ELIZABETH FRANCES · 2020 to 2023
$3.0M
NHLBI NIH HHS R01 HL149741NIAID NIH HHS R01 AI141389
6 · The paper itself

Abstract

Introduction: Loss of NADPH oxidase activity results in proinflammatory macrophages that contribute to hyperinflammation in Chronic Granulomatous Disease (CGD). Previously, it was shown in a zymosan-induced peritonitis model that gp91 Methods: We sought to identify key constituents using Results: More extensive phenotyping defined normal MoMac maturation and demonstrated failure of maturation of CGD MoMacs both Discussion: These data lend mechanistic insights into the utility of TNFα blockade in CGD and to other diseases where such therapy has been shown to be beneficial.

Indexed as

Granulomatous Disease, ChronicReceptors, Tumor Necrosis Factor, Type ITumor Necrosis Factor-alphaAnimalsCulture Media, ConditionedCytokinesMacrophagesMiceNADPH OxidasesCulture Media, ConditionedCytokinesNADPH OxidasesReceptors, Tumor Necrosis Factor, Type ITnfrsf1a protein, mouseTumor Necrosis Factor-alphachronic granulomatous disease (CGD)hyperinflammationmacrophage programmingmonocyte-derived macrophagesTNF inhibitortumor necrosis factor

Identifiers

PMID38404573
PMCPMC10884288
OpenAlexW4391689798

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.