Evidence map›Paper›PMID 38404571›Full record

ArticleFrontiers in immunology2024

MGMT unmethylation and high levels of CD47 and TIGIT indicate a poor prognosis in adult diffuse gliomas.

Lingbo Ma, Yi Shi, Chang Li, Bin Deng, Jinfang Jiang, Yuwen Cao, Lianghai Wang, Hongyan Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Lingbo Ma *NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital/Shihezi University School of Medicine, Shihezi, China.
Yi Shi *Department of Pathology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Chang LiDepartment of Cardiothoracic Surgery, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University, Zhuhai, China.
Bin DengDepartment of Medical Record Statistics, Northeast Yunnan Regional Central Hospital, Zhaotong, China.
Jinfang JiangNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital/Shihezi University School of Medicine, Shihezi, China.
Yuwen CaoNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital/Shihezi University School of Medicine, Shihezi, China.
Lianghai WangNHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, The First Affiliated Hospital/Shihezi University School of Medicine, Shihezi, China.
Hongyan LiDepartment of Neurology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China.
Shihezi University · CNFirst Affiliated Hospital of Xinjiang Medical University · CNJinan University · CNPeople's Hospital of Xinjiang Uygur Autonomous Region · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: In 2021, the World Health Organization published a new classification system for central nervous system tumors. This study reclassified the adult diffuse glioma (ADG) into astrocytoma, oligodendroglioma, and glioblastoma (GBM) according to the new tumor classification. Methods: The association of TERT promoter (pTERT) mutation, MGMT methylation, and CD47/TIGIT expression with patient prognosis was investigated. Results: Immunohistochemical analysis showed that the expression levels of CD47 and TIGIT in tumor tissues were significantly higher than those in normal brain tissues. CD47 levels were higher in GBM and grade 4 astrocytoma tissues. TIGIT expression was also higher in patients with GBM. The high expressions of CD47, TIGIT, and CD47/TIGIT were positively correlated with Discussion: Collectively, these results showed that the

Indexed as

AstrocytomaBrain NeoplasmsGlioblastomaGliomaAdultCD47 AntigenDNA Modification MethylasesDNA Repair EnzymesHumansPrognosisReceptors, ImmunologicTumor Suppressor ProteinsCD47 AntigenCD47 protein, humanDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanReceptors, ImmunologicTIGIT protein, humanTumor Suppressor Proteinsadult-type diffuse gliomaCD47IDH mutantMGMT methylationpTERT mutationTIGIT

Identifiers

PMID38404571
PMCPMC10884119
OpenAlexW4391689658

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.