Evidence map›Paper›PMID 38404508›Full record

ArticleComprehensive psychoneuroendocrinology2024

Preliminary results of anti-inflammatory cytokine concentrations predicting therapy outcome in panic disorder.

Vanessa Renner, Rupert Conrad, Clemens Kirschbaum, Thomas Lorenz, Katja Petrowski

Registry-linked trialAbstract read
In one paragraph

Article in Comprehensive psychoneuroendocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06514495 (Differential Effects of in Vivo and Virtual Exposure Therapy on the Interoception and Reactivity of Different Body Systems in Agoraphobia), which is not on this map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06514495 narecruitingnot on this mapstarted 2025, after this paper: background citation

Differential Effects of in Vivo and Virtual Exposure Therapy on the Interoception and Reactivity of Different Body Systems in Agoraphobia

TypeinterventionalSponsorJohannes Gutenberg University MainzRan2025 to 2027Enrolled68ConditionsAgoraphobia, Panic, Social Anxiety DisorderArmsTherapy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Vanessa RennerDepartment of Medical Psychology and Medical Sociology, University Medical Center of the Johannes Gutenberg-University Mainz, Duesbergweg 6, 55128, Mainz, Germany.
Rupert ConradDepartment of Psychosomatic Medicine and Psychotherapy, University Hospital Muenster, Albert-Schweitzer-Campus 1, 48149, Muenster, Germany.
Clemens KirschbaumDepartment of Psychology, Institute of Biological Psychology, Technische Universität Dresden, Zellescher Weg 19, 01069, Dresden, Germany.
Thomas LorenzUniversity Medical Center Carl Gustav Carus, Technische Universität Dresden, Fetscherstraße 74, 01307, Dresden, Germany.
Katja PetrowskiDepartment of Medical Psychology and Medical Sociology, University Medical Center of the Johannes Gutenberg-University Mainz, Duesbergweg 6, 55128, Mainz, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Patients with panic disorder (PD) show alterations of the immune reactivity to acute stress, which could serve as a marker for effective treatment. Nevertheless, the effect of immune reactivity under acute stress before treatment on therapy outcome remains unclear. Methods: A total of Results: AUC Conclusion: Higher concentrations of anti-inflammatory cytokine IL-10 under acute stress before treatment predicts less avoidance behavior in company after therapy. Immune markers seem to play a crucial role in the maintenance of mental disorders such as PD. Underlying mechanisms and IL-10 as a marker for individualized treatments should be investigated in future studies.

Indexed as

CytokinesPanic disorderTSST

Identifiers

PMID38404508
PMCPMC10891278

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.