ReviewChemical science2024
A review of frustrated Lewis pair enabled monoselective C-F bond activation.
Review in Chemical science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Bayesian optimization- and high-throughput-guided synthesis of monofluoroalkenesChemical science · 2026Article
- Net fluorine atom transfer from the perspective of a PCET chemist.Chemical communications (Cambridge, England) · 2026Review
- Intramolecular Al/P Frustrated Lewis Pairs Based on an Indoline Backbone─Two Reaction Sites for Small Molecule Activation and Hydrodefluorination.Inorganic chemistry · 2026Article
- Conversion of trifluoromethyls into esters along with polyether upcyclingChemical science · 2026Article
- A Brønsted acid-base approach for the net monoselective C-F substitution of (trifluoromethyl)alkanes.Chemical science · 2026Article
- A comparative study of frustration in Al/P and B/P-based intramolecular frustrated Lewis pairs.RSC advances · 2025Article
- Monodefluorinative Halogenation of Perfluoroalkyl Ketones via Organophosphorus-Mediated Selective C-F Activation.JACS Au · 2025Article
- Cryogenic Organometallic Carbon-Fluoride Bond Functionalization with Broad Functional Group Tolerance.Journal of the American Chemical Society · 2025Article
- Chemodivergent alkylation of trifluoromethyl alkenesGreen chemistry : an international journal and green chemistry resource : GC · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Frustrated Lewis pair (FLP) bond activation chemistry has greatly developed over the last two decades since the seminal report of metal-free reversible hydrogen activation. Recently, FLP systems have been utilized to allow monoselective C-F bond activation (at equivalent sites) in polyfluoroalkanes. The problem of 'over-defluorination' in the functionalization of polyfluoroalkanes (where multiple fluoro-positions are uncontrollably functionalized) has been a long-standing chemical problem in fluorocarbon chemistry for over 80 years. FLP mediated monoselective C-F bond activation is complementary to other solutions developed to address 'over-defluorination' and offers several advantages and unique opportunities. This perspective highlights some of these advantages and opportunities and places the development of FLP mediated C-F bond activation into the context of the wider effort to overcome 'over-defluorination'.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.