Evidence map›Paper›PMID 38404358›Full record

ArticleACS applied nano materials2021

Dual-Shaped Silver Nanoparticle Labels for Electrochemical Detection of Bioassays.

Nicole E Pollok, Yi Peng, Nikhil Raj, Charuksha Walgama, Richard M Crooks

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied nano materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Nicole E PollokDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St., Stop A1590, Austin, Texas, 78712-1224, USA.
Yi PengDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St., Stop A1590, Austin, Texas, 78712-1224, USA.
Nikhil RajDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St., Stop A1590, Austin, Texas, 78712-1224, USA.
Charuksha WalgamaDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St., Stop A1590, Austin, Texas, 78712-1224, USA.
Richard M CrooksDepartment of Chemistry, The University of Texas at Austin, 100 E. 24th St., Stop A1590, Austin, Texas, 78712-1224, USA.
The University of Texas at Austin · US

Funding

A disposable NT-proBNP sensor for managing heart failure at homeR01HL137601 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI CROOKS, RICHARD M · 2017 to 2020
$2.0M
NHLBI NIH HHS R01 HL137601
6 · The paper itself

Abstract

In this paper we demonstrate the use of dual-shaped silver nanoparticles (AgNPs) as detection labels for electrochemical bioassays. The key finding is that by using AgNP labels having two different shapes simultaneously, the limit of detection (LOD) for the assays is lowered compared to using either of the two shapes separately. The two shapes were silver nanocubes (AgNCs) having edge lengths of 40 ± 4 nm and spherical AgNPs (sAgNPs) having diameters of 20 ± 3 nm. Two different bioassays were examined. In both cases the Ag labels were functionalized with antibodies. In the one assay, the labels are directly linked to a second antibody immobilized on magnetic beads. In the second assay, the antibodies on the AgNP labels and the antibodies on the magnetic beads are linked via a peptide. The peptide is N-terminal prohormone brain natriuretic peptide (NT-proBNP), which is a heart failure marker. The efficacy of the two electrochemical assays as a function of the ratio of the two labels was investigated using a galvanic exchange/anodic stripping voltammetry method. The key finding is that by optimizing the ratio of the two types of AgNP labels, it is possible to decrease the LOD of the assays without compromising the dynamic range compared to using either of the two labels independently. This made it possible to achieve the clinically relevant range for NT-proBNP analysis used by physicians for heart failure risk stratification.

Indexed as

galvanic exchangeheart failuremetalloimmunoassayN-terminal prohormone brain natriuretic peptidesilver nanocubesspherical silver nanoparticles

Identifiers

PMID38404358
PMCPMC10888530
OpenAlexW3205048790

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.