Evidence map›Paper›PMID 38404297›Full record

ArticleBiomedical optics express2024

Optical biosensor based on weak measurement for ultra-sensitive detection of calreticulin in human serum.

Zhikang Peng, Jiali Chen, Yufei Liu, Dongmei Li, Yixiao Li, Qihao Zhang, Chaoyi Chen, Ying Zhang, Jia Yao, Shuqian Wang and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Zhikang PengKey Laboratory of Quantum Precision Measurement of Zhejiang Province, Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China.
Jiali ChenKey Laboratory of Quantum Precision Measurement of Zhejiang Province, Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China.
Yufei LiuKey Laboratory of Quantum Precision Measurement of Zhejiang Province, Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China.ORCID https://orcid.org/0009-0007-0298-9253
Dongmei LiKey Laboratory of Quantum Precision Measurement of Zhejiang Province, Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China.
Yixiao LiKey Laboratory of Quantum Precision Measurement of Zhejiang Province, Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China.
Qihao ZhangKey Laboratory of Quantum Precision Measurement of Zhejiang Province, Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China.
Chaoyi ChenKey Laboratory of Quantum Precision Measurement of Zhejiang Province, Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China.
Ying ZhangDepartment of Endocrinology and Metabolism, Shaoxing Second Hospital, Shaoxing 312000, China.
Jia YaoDepartment of Breast Surgery, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 311121, China.
Shuqian WangDepartment of Breast Surgery, the First Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 311121, China.
Qiang LinKey Laboratory of Quantum Precision Measurement of Zhejiang Province, Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China.ORCID https://orcid.org/0000-0002-4959-0609
Yi RuanKey Laboratory of Quantum Precision Measurement of Zhejiang Province, Center for Optics & Optoelectronics Research, Collaborative Innovation Center for Information Technology in Biological and Medical Physics, College of Science, Zhejiang University of Technology, Hangzhou 310023, China.ORCID https://orcid.org/0000-0002-9348-298X
Zhejiang University of Technology · CNFirst Affiliated Hospital Zhejiang University · CNShaoxing Second Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A novel real-time optical phase sensing method based on the Mach-Zehnder interference principle has been proposed for the detection of calreticulin (CRT) levels in human serum samples. In this approach, anti-CRT antibodies are utilized to capture CRT molecules in serum, leading to a phase shift in both the measuring and reference arms of the system. By employing the concept of weak amplification within the framework of weak measurements, it becomes feasible to continuously monitor the response of CRT in real-time, allowing for the precise determination of serum CRT content at the picomolar level. Our achievement may pave the way in establishing CRT as a diagnostic biomarker for a wide range of medical applications, including rheumatoid arthritis.

Identifiers

PMID38404297
PMCPMC10890857
OpenAlexW4390588216

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.