Evidence map›Paper›PMID 38404246›Full record

ArticleJournal of perinatal medicine2024

Correlation of fetal heart rate dynamics to inflammatory markers and brain-derived neurotrophic factor during pregnancy.

Luis Mercado, Shannon Rose, Diana Escalona-Vargas, Eric R Siegel, Julie R Whittington, Hubert Preissl, Melissa Helmich, Hari Eswaran

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of perinatal medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Luis MercadoDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Shannon RoseDepartment of Pediatrics, Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Diana Escalona-VargasDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Eric R SiegelDepartment of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Julie R WhittingtonDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Hubert PreisslInstitute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, German Center for Diabetes Research (DZD), Tübingen, Germany.
Melissa HelmichDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
Hari EswaranDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.
University of Arkansas for Medical Sciences · USArkansas Children's Hospital · USDeutsches Diabetes-Zentrum e.V. · DE

Funding

The Role of the Mitochondrion in the Metabolic Stress Response to Burn TraumaP20GM109096 · NIGMS · ARKANSAS CHILDREN'S HOSPITAL RES INST · PI SWINDLE, TAREN · 2016 to 2025
$20.7M
Magnetoencephalography based tracking of fetal neurodevelopment in diabetic pregnanciesR01HD105412 · NICHD · UNIV OF ARKANSAS FOR MED SCIS · PI ESCALONA-VARGAS, DIANA · 2021 to 2024
$1.5M
Development of Analysis Tools to Enhance Fetal Neurological AssessmentR01EB007826 · NIBIB · UNIV OF ARKANSAS FOR MED SCIS · PI ESWARAN, HARI · 2007 to 2013
$1.4M
NIBIB NIH HHS R01 EB007826NICHD NIH HHS R01 HD105412NIGMS NIH HHS P20 GM109096
6 · The paper itself

Abstract

objectivesThis study aims to show the relation between biomarkers in maternal and cord-blood samples and fetal heart rate variability (fHRV) metrics through a non-invasive fetal magnetocardiography (fMCG) technique.

methodsTwenty-three women were enrolled for collection of maternal serum and fMCG tracings immediately prior to their scheduled cesarean delivery. The umbilical cord blood was collected for measurement of biomarker levels. The fMCG metrics were then correlated to the biomarker levels from the maternal serum and cord blood.

resultsBrain-derived neurotrophic factor (BDNF) had a moderate correlation with fetal parasympathetic activity (0.416) and fetal sympathovagal ratios (-0.309; -0.356). Interleukin (IL)-6 also had moderate-sized correlations but with an inverse relationship as compared to BDNF. These correlations were primarily in cord-blood samples and not in the maternal blood.

conclusionsIn this small sample-sized exploratory study, we observed a moderate correlation between fHRV and cord-blood BDNF and IL-6 immediately preceding scheduled cesarean delivery at term. These findings need to be validated in a larger population.

Indexed as

BiomarkersBrain-Derived Neurotrophic FactorFetal BloodHeart Rate, FetalInterleukin-6AdultCesarean SectionFemaleHumansMagnetocardiographyPregnancyBDNF protein, humanBiomarkersBrain-Derived Neurotrophic FactorIL6 protein, humanInterleukin-6brain-derived neurotrophic factor (BDNF)fetal heart rate variabilityfetal magnetocardiographyinflammatory markers (IL-6)

Identifiers

PMID38404246
PMCPMC11068021
OpenAlexW4392159598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.