Evidence map›Paper›PMID 38403772›Full record

ArticleInternal medicine (Tokyo, Japan)2024

A Prompt Diagnosis and Treatment of a Case of Nuclear Protein of the Testis Carcinoma Characterized by a Bronchial Lesion and High Serum Alpha-fetoprotein Level Following Genomic Testing.

Hiroaki Matsuura, Go Makimoto, Naohiro Oda, Kiichiro Ninomiya, Hisao Higo, Masanori Fujii, Kammei Rai, Eiki Ichihara, Kadoaki Ohashi, Katsuyuki Hotta and 2 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hiroaki MatsuuraDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Go MakimotoDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Naohiro OdaDepartment of Respiratory Medicine, Fukuyama City Hospital, Japan.
Kiichiro NinomiyaCenter for Comprehensive Genomic Medicine, Okayama University Hospital, Japan.
Hisao HigoDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Masanori FujiiDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Kammei RaiCenter for Innovative Clinical Medicine, Okayama University Hospital, Japan.
Eiki IchiharaDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Kadoaki OhashiDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Katsuyuki HottaCenter for Innovative Clinical Medicine, Okayama University Hospital, Japan.
Masahiro TabataCenter for Clinical Oncology, Okayama University Hospital, Japan.
Yoshinobu MaedaDepartment of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nuclear protein of the testis carcinoma (NUTC) is a rare and aggressive malignancy. We herein report a case of NUTC in the lung characterized by a bronchial lesion and elevated alpha-fetoprotein levels. A 35-year-old Japanese man presented to our institution with suspected advanced lung cancer based on a histological examination. Subsequently, next-generation sequencing (NGS) yielded a positive BRD4-NUTM1 fusion. In addition, positive NUT immunostaining of the lung biopsy specimen confirmed NUTC in the lungs. Systemic chemotherapy and radiotherapy showed a temporary response, with decreased serum alpha-fetoprotein levels. We highlight this case of a prompt diagnosis by NGS of NUTC in a young individual with a rapidly progressing tumor.

Indexed as

alpha-FetoproteinsLung NeoplasmsNuclear ProteinsAdultHigh-Throughput Nucleotide SequencingHumansMaleNeoplasm ProteinsOncogene Proteins, Fusionalpha-FetoproteinsBRD4-NUT fusion oncogene protein, humanNeoplasm ProteinsNuclear ProteinsNUTM1 protein, humanOncogene Proteins, Fusionalpha-fetoprotein (AFP)BRD4-NUTM1immune checkpoint inhibitorlung cancerNUT carcinoma

Identifiers

PMID38403772
PMCPMC11518595

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.