Evidence map›Paper›PMID 38402616›Full record

ArticleCurrent biology : CB2024

Organization of an ascending circuit that conveys flight motor state in Drosophila.

Han S J Cheong, Kaitlyn N Boone, Marryn M Bennett, Farzaan Salman, Jacob D Ralston, Kaleb Hatch, Raven F Allen, Alec M Phelps, Andrew P Cook, Jasper S Phelps and 5 more

Abstract read
In one paragraph

Article in Current biology : CB, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Insect Flight: State of the Field and Future Directions.Integrative and comparative biology · 2024
    Article
  7. Comparative connectomics of the descending and ascending neurons of thebioRxiv : the preprint server for biology · 2024
    Article
  8. Article
  9. A Closer Look at Histamine inInternational journal of molecular sciences · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Han S J CheongDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA; Zuckerman Institute, Columbia University, New York, NY 10027, USA.
Kaitlyn N BooneDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA; Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
Marryn M BennettDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA.
Farzaan SalmanDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA.
Jacob D RalstonDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA.
Kaleb HatchDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA.
Raven F AllenDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA.
Alec M PhelpsDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA.
Andrew P CookDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA.
Jasper S PhelpsDepartment of Neurobiology, Harvard Medical School, Boston, MA 02115, USA; Swiss Federal Institute of Technology Lausanne, 1015 Lausanne, Switzerland.
Mert ErginkayaChampalimaud Research, Champalimaud Centre for the Unknown, Lisbon 1400-038, Portugal.
Wei-Chung A LeeF.M. Kirby Neurobiology Center, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Gwyneth M CardJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA; Zuckerman Institute, Columbia University, New York, NY 10027, USA.
Kevin C DalyDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA; Department of Neuroscience, West Virginia University, Morgantown, WV 26505, USA.
Andrew M DacksDepartment of Biology, West Virginia University, Morgantown, WV 26505, USA; Department of Neuroscience, West Virginia University, Morgantown, WV 26505, USA. Electronic address: andrew.dacks@mail.wvu.edu.

Funding

Tools to broaden access to high-throughput functional connectomicsRF1MH117808 · NIMH · HARVARD MEDICAL SCHOOL · PI LEE, WEI-CHUNG ALLEN, MACRINA, THOMAS · 2019 to 2019
$4.3M
Automating whole brain connectomics: development, validation, and application of an open toolkitRF1MH120679 · NIMH · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BOCK, DAVI · 2019 to 2019
$1.9M
NIMH NIH HHS RF1 MH117808NIMH NIH HHS RF1 MH120679
6 · The paper itself

Abstract

Natural behaviors are a coordinated symphony of motor acts that drive reafferent (self-induced) sensory activation. Individual sensors cannot disambiguate exafferent (externally induced) from reafferent sources. Nevertheless, animals readily differentiate between these sources of sensory signals to carry out adaptive behaviors through corollary discharge circuits (CDCs), which provide predictive motor signals from motor pathways to sensory processing and other motor pathways. Yet, how CDCs comprehensively integrate into the nervous system remains unexplored. Here, we use connectomics, neuroanatomical, physiological, and behavioral approaches to resolve the network architecture of two pairs of ascending histaminergic neurons (AHNs) in Drosophila, which function as a predictive CDC in other insects. Both AHN pairs receive input primarily from a partially overlapping population of descending neurons, especially from DNg02, which controls wing motor output. Using Ca

Indexed as

DrosophilaNeuronsAnimalsEfferent PathwaysInsectaascending neuronconnectomicscorollary discharge circuitefference copyventral nerve cord

Identifiers

PMID38402616
PMCPMC10939832

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.