Evidence map›Paper›PMID 38402352›Full record

ArticleScientific reports2024

Dynamic contrast-enhanced magnetic resonance imaging assessment of residual tumor angiogenesis after insufficient microwave ablation and donafenib adjuvant therapy.

Ziwang Ren, Guiling Feng, Bing Li, Chuan Zhang, Yong Du

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Ziwang RenDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 1 Maoyuan Road, Nanchong City, 637000, Sichuan Province, China.ORCID 0009-0005-0184-2917
Guiling FengDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 1 Maoyuan Road, Nanchong City, 637000, Sichuan Province, China.ORCID 0000-0001-5122-3325
Bing LiDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 1 Maoyuan Road, Nanchong City, 637000, Sichuan Province, China.ORCID 0000-0003-3468-6322
Chuan ZhangDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 1 Maoyuan Road, Nanchong City, 637000, Sichuan Province, China.ORCID 0000-0003-4621-9780
Yong DuDepartment of Radiology, Affiliated Hospital of North Sichuan Medical College, 1 Maoyuan Road, Nanchong City, 637000, Sichuan Province, China. duyong@nsmc.edu.cn.ORCID 0000-0002-8119-3195
North Sichuan Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To analyze the correlation between dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) permeability parameters and serum vascular endothelial growth factor (VEGF) levels in a rabbit VX2 liver cancer model with insufficient microwave ablation (MWA), to observe the dynamic changes in residual tumor angiogenesis in the short term after MWA, and to assess the effectiveness of donafenib as adjuvant therapy. Forty rabbits with VX2 liver tumors were randomly divided into three groups: an insufficient MWA group (n = 15), a combined treatment group (n = 15) and a control group (n = 10). The dynamic changes in VEGF expression after MWA and the effectiveness of donafenib as adjuvant therapy were evaluated by DCE-MRI and serum VEGF levels before surgery and 1, 3, 7, and 14 days after surgery. The correlation between the volume translate constant (Ktrans) of DCE-MRI parameters and serum VEGF levels fluctuated after ablation, but the coefficient was always positive (all p < 0.001). Repeated-measures ANOVA revealed significant changes in the serum VEGF concentration (F = 40.905, p < 0.001; partial η

Indexed as

Liver NeoplasmsPyridinesVascular Endothelial Growth Factor AAngiogenesisAnimalsContrast MediaMagnetic Resonance ImagingMicrowavesNeoplasm, ResidualNeovascularization, PathologicRabbitsContrast MediadonafenibPyridinesVascular Endothelial Growth Factor ADCE-MRIDonafenibMicrowave ablationVEGFVX2

Identifiers

PMID38402352
PMCPMC10894284
OpenAlexW4392130436

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.