ArticleScientific reports2024
High-voltage pulsed radiofrequency improves ultrastructure of DRG and enhances spinal microglial autophagy to ameliorate neuropathic pain induced by SNI.
Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Effects of pulsed radiofrequency combined with ozone on zoster-associated pain: a systematic review and meta-analysis.Medical gas research · 2026Pooled it
- Ultrasound-guided high-voltage pulsed radiofrequency versus standard-voltage pulsed radiofrequency in refractory chronic cervical radicular pain randomized clinical trial.Journal of anesthesia · 2025Trial
- The Leiden-Nice Consensus (2024-2025)-Technical Standardization and Clinical Algorithms for Pulsed Radiofrequency for Chronic Pain.Pain and therapy · 2026Review
- Pulsed radiofrequency attenuates mechanical hypersensitivity in neuropathic pain rats by activating the Nrf2-regulated CaMKII/NF-κB signaling pathway.The Korean journal of pain · 2026Article
- Elucidation of the treatment mechanism of pulsed radiofrequency based on its antiinflammatory effects.Scientific reports · 2025Article
- A narrative review of autophagy in migraine.Frontiers in neuroscience · 2025Review
- Pulsed Radiofrequency Relieves Neuropathic Pain by Repairing the Ultrastructural Damage of Chronically Compressed Dorsal Root Ganglion.Neuroscience insights · 2025Article
- Microglia and programmed cell death in spinal cord injury: beyond apoptosis.Frontiers in cell and developmental biology · 2025Review
- Efficacy and Safety of Pulsed Radiofrequency Combined with Platelet-Rich Plasma in the Treatment of Postherpetic Neuralgia: A Systematic Review and Meta-Analysis.Journal of pain research · 2025Review
- PDCD4 inhibition alleviates neuropathic pain by regulating spinal autophagy and neuroinflammation.Molecular painArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Neuropathic pain (NeP) is intractable for which many therapies are ineffective. High-voltage pulsed radiofrequency (HVPRF) on dorsal root ganglion (DRG) is considered an effective treatment for NeP. The aim of this study is to explore the therapeutic voltage for the optimal efficacy of PRF and the underlying mechanisms. The radiofrequency electrode was placed close to the L5 DRG of rats with spared nerve injury (SNI) and emitted current by the corresponding voltage in different groups. Four different voltages (45 V, 65 V, 85 V, and 100 V) of PRF on DRG significantly alleviated the SNI-induced NeP, reduced the levels of activating transcription factor 3 (ATF3) in DRG, improved the ultrastructure of DRG, and promoted autophagy in spinal microglia to varying degrees and partially reversed the increased expression of TNF-α and the reduced expression of IL-10 in spinal cord dorsal horn (SCDH). The beneficial effect of 85V-PRF was superior to those of other three PRF treatments. The underlying mechanisms may be related to repairing the DRG damage and improving the DRG ultrastructure while regulating spinal microglial autophagy and thereby alleviating neuroinflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.