Evidence map›Paper›PMID 38402193›Full record

ReviewCell communication and signaling : CCS2024

Apoptosis dysfunction: unravelling the interplay between ZBP1 activation and viral invasion in innate immune responses.

Jianhao Zhan, Jisheng Wang, Yuqing Liang, Lisha Wang, Le Huang, Shanshan Liu, Xiaoping Zeng, Erming Zeng, Hongmei Wang

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell communication and signaling : CCS, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

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  16. When ASFV Infection Meets the cGAS-STING Signaling Pathway.Transboundary and emerging diseases · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jianhao Zhan *Department of Neurosurgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Jisheng Wang *Department of Neurosurgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Yuqing Liang *School of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Lisha WangHuanKui Academy, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Le HuangHuanKui Academy, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Shanshan LiuSchool of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Xiaoping ZengSchool of Basic Medical Sciences, Nanchang University, Nanchang, Jiangxi Province, 330006, China.
Erming ZengDepartment of Neurosurgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China. ndyfy02081@ncu.edu.cn.
Hongmei WangDepartment of Neurosurgery, the First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi Province, 330006, China. 20231013@jhc.edu.cn.
Nanchang University · CN

Funding

Jiangxi Provincial Natural Science Foundation Nos. 20224BAB206068Key Research and Development Program of Jiangxi Province Nos. 20202BBG73030National Natural Science Foundation of China Nos. 82060526
6 · The paper itself

Abstract

Apoptosis plays a pivotal role in pathogen elimination and maintaining homeostasis. However, viruses have evolved strategies to evade apoptosis, enabling their persistence within the host. Z-DNA binding protein 1 (ZBP1) is a potent innate immune sensor that detects cytoplasmic nucleic acids and activates the innate immune response to clear pathogens. When apoptosis is inhibited by viral invasion, ZBP1 can be activated to compensate for the effect of apoptosis by triggering an innate immune response. This review examined the mechanisms of apoptosis inhibition and ZBP1 activation during viral invasion. The authors outlined the mechanisms of ZBP1-induced type I interferon, pyroptosis and necroptosis, as well as the crosstalk between ZBP1 and the cGAS-STING signalling pathway. Furthermore, ZBP1 can reverse the suppression of apoptotic signals induced by viruses. Intriguingly, a positive feedback loop exists in the ZBP1 signalling pathway, which intensifies the innate immune response while triggering a cytokine storm, leading to tissue and organ damage. The prudent use of ZBP1, which is a double-edged sword, has significant clinical implications for treating infections and inflammation.

Indexed as

ApoptosisImmunity, InnateCytoplasmHumansInflammationPyroptosisApoptosis inhibitionInnate immunityViral invasionZBP1

Identifiers

PMID38402193
PMCPMC10893743
OpenAlexW4392129304

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.