ArticleNature communications2024
Induced neural phase precession through exogenous electric fields.
Article in Nature communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
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- Phase-tuned modulation during reward expectancy in human anterior insular cortex.Communications biology · 2026Article
- The Heart's Electromagnetic Field in Emotions, Empathy and Human Connection: Biosensor-Derived Insights into Heart-Brain Axis Mechanisms and a Basis for Novel BioMagnetoTherapies.Sensors (Basel, Switzerland) · 2026Review
- Intensity-dependent tACS entrainment effects in a cortical microcircuit: a computational study.Scientific reports · 2026Article
- Nested spatiotemporal theta-gamma waves organize hierarchical processing across the mouse visual cortex.Nature communications · 2026Article
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- Theta Transcranial Alternating Current Stimulation Over the Dorsomedial Prefrontal Cortex Does Not Enhance Long-Term Memory.The European journal of neuroscience · 2026Article
- Review
- Brain stimulation preferentially influences long-range projections.Science advances · 2025Article
- Layers of the monkey visual cortex are selectively modulated during electrical stimulation.PLoS biology · 2025Article
- Modulation of motor excitability reflects traveling waves of neural oscillations.Cell reports · 2025Article
- Comprehensive evaluation of U-Net based transcranial magnetic stimulation electric field estimations.Scientific reports · 2025Article
- μ-Transcranial Alternating Current Stimulation Induces Phasic Entrainment and Plastic Facilitation of Corticospinal Excitability.The European journal of neuroscience · 2025Article
- Editorial: Transcranial electrical stimulation (tACS, tDCS, tRNS) in basic and clinical neuroscience: current progress and future directions.Frontiers in human neuroscience · 2025Article
- Neuroplastic effects of transcranial alternating current stimulation (tACS): from mechanisms to clinical trials.Frontiers in human neuroscience · 2025Review
- Effects of AC induced electric fields on neuronal firing sensitivity and activity patterns.Frontiers in computational neuroscience · 2025Article
- Dose-response of tDCS effects on motor learning and cortical excitability: A preregistered study.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Aligning Event-Related Potentials with Transcranial Alternating Current Stimulation for Modulation-a Review.Brain topography · 2024Review
- Real-time TMS-EEG for brain state-controlled research and precision treatment: a narrative review and guide.Journal of neural engineering · 2024Review
- State-Dependent tACS Effects Reveal the Potential Causal Role of Prestimulus Alpha Traveling Waves in Visual Contrast Detection.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
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10 authors at 1 institution in 1 country.
Funding
Abstract
The gradual shifting of preferred neural spiking relative to local field potentials (LFPs), known as phase precession, plays a prominent role in neural coding. Correlations between the phase precession and behavior have been observed throughout various brain regions. As such, phase precession is suggested to be a global neural mechanism that promotes local neuroplasticity. However, causal evidence and neuroplastic mechanisms of phase precession are lacking so far. Here we show a causal link between LFP dynamics and phase precession. In three experiments, we modulated LFPs in humans, a non-human primate, and computational models using alternating current stimulation. We show that continuous stimulation of motor cortex oscillations in humans lead to a gradual phase shift of maximal corticospinal excitability by ~90°. Further, exogenous alternating current stimulation induced phase precession in a subset of entrained neurons (~30%) in the non-human primate. Multiscale modeling of realistic neural circuits suggests that alternating current stimulation-induced phase precession is driven by NMDA-mediated synaptic plasticity. Altogether, the three experiments provide mechanistic and causal evidence for phase precession as a global neocortical process. Alternating current-induced phase precession and consequently synaptic plasticity is crucial for the development of novel therapeutic neuromodulation methods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.