Evidence map›Paper›PMID 38401789›Full record

Trial reportThe Journal of pediatrics2024

Preliminary Impact of Group-Based Interventions on Stigma, Mental Health, and Treatment Adherence Among Adolescents Living with Human Immunodeficiency Virus in Uganda.

Proscovia Nabunya, Fred M Ssewamala, Samuel Kizito, James Mugisha, Rachel Brathwaite, Torsten B Neilands, Herbert Migadde, Flavia Namuwonge, Vicent Ssentumbwe, Claire Najjuuko and 3 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in The Journal of pediatrics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04528732 (Suubi4Stigma), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04528732 nacompletednot on this map

Suubi4Stigma: Addressing HIV-Associated Stigma Among Adolescents

TypeinterventionalSponsorWashington University School of MedicineRan2020 to 2022Enrolled89ConditionsHIV/AIDSArmsGroup Cognitive Behavioral Therapy (G-CBT), Multiple Family Group (MFG)
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Proscovia NabunyaInternational Center for Child Health and Development (ICHAD), Brown School Washington University in St. Louis, St. Louis, MO. Electronic address: nabunyap@wustl.edu.
Fred M SsewamalaInternational Center for Child Health and Development (ICHAD), Brown School Washington University in St. Louis, St. Louis, MO.
Samuel KizitoInternational Center for Child Health and Development (ICHAD), Brown School Washington University in St. Louis, St. Louis, MO.
James MugishaCollege of Health Sciences, Makerere University, Kampala, Uganda.
Rachel BrathwaiteInternational Center for Child Health and Development (ICHAD), Brown School Washington University in St. Louis, St. Louis, MO.
Torsten B NeilandsDivision of Prevention Science, School of Medicine, University of California San Francisco, San Francisco, CA.
Herbert MigaddeInternational Center for Child Health and Development (ICHAD) Field Office, Masaka, Uganda.
Flavia NamuwongeInternational Center for Child Health and Development (ICHAD), Brown School Washington University in St. Louis, St. Louis, MO.
Vicent SsentumbweInternational Center for Child Health and Development (ICHAD), Brown School Washington University in St. Louis, St. Louis, MO.
Claire NajjuukoDivision of Computational & Data Sciences, McKelvey School of Engineering, Washington University in St. Louis, St. Louis, MO.
Ozge Sensoy BaharInternational Center for Child Health and Development (ICHAD), Brown School Washington University in St. Louis, St. Louis, MO.
Abel MwebembeziReach the Youth, Kampala, Uganda.
Mary M McKayVice Provost Office, Washington University in St. Louis, St. Louis, MO.

Funding

Ujima Mentoring ProgramP30MH062246 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MALLORY O JOHNSON · 2001 to 2026
$57.4M
Training Program for Scientists Conducting Research to Reduce HIV Health DisparitR25MH067127 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Emily A Arnold, Torsten Brian Neilands · 2003 to 2026
$5.4M
Strengthening Child Health Research Capacity in Resource Constrained Settings: Researcher Resilience Training (RRT)R25MH118935 · NIMH · WASHINGTON UNIVERSITY · PI SEAN JOE, Mary McKernan McKay · 2018 to 2026
$1.5M
Suubi4Stigma: Addressing HIV-Associated Stigma Among AdolescentsR21MH121141 · NIMH · WASHINGTON UNIVERSITY · PI NABUNYA, PROSCOVIA, SSEWAMALA, FRED M · 2020 to 2021
$425k
NIMH NIH HHS P30 MH062246NIMH NIH HHS R21 MH121141NIMH NIH HHS R25 MH067127NIMH NIH HHS R25 MH118935
6 · The paper itself

Abstract

objectiveTo examine the preliminary impact of group cognitive behavioral therapy and multiple family group-based family strengthening to address HIV stigma and improve the mental health functioning of adolescents living with HIV in Uganda. STUDY

designWe analyzed data from the Suubi4Stigma study, a 2-year pilot randomized clinical trial that recruited adolescents living with HIV (10-14 years) and their caregivers (n = 89 dyads), from 9 health clinics. We fitted separate three-level mixed-effects linear regression models to test the effect of the interventions on adolescent outcomes at 3 and 6 months post intervention initiation.

resultsThe average age was 12.2 years and 56% of participants were females. Participants in the multiple family group-based family strengthening intervention reported lower levels of internalized stigma (mean difference = -0.008, 95% CI = -0.015, -0.001, P = .025) and depressive symptoms at 3 months (mean difference = -0.34, 95% CI = -0.53, -0.14, P < .001), compared with usual care. On the other hand, participants in the group cognitive behavioral therapy intervention reported lower levels of anticipated stigma at 3 months (mean difference = -0.039, 95% CI = -0.072, -0.006), P = .013) and improved self-concept at 6 months follow-up (mean difference = 0.04, 95% CI = 0.01, 0.01, P = .025).

conclusionOutcome trends from this pilot study provide compelling evidence to support testing the efficacy of these group-based interventions on a larger scale.

trial registrationThe study is registered in the Clinical trials.gov database (Identifier #: NCT04528732).

Indexed as

Cognitive Behavioral TherapyHIV InfectionsPsychotherapy, GroupSocial StigmaAdolescentCaregiversChildFemaleHumansMaleMental HealthPilot ProjectsTreatment Adherence and ComplianceUgandacognitive behavioral therapydepressive symptomsfamily strengtheningHIV stigmamultiple family group

Identifiers

PMID38401789
PMCPMC11095998

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.