Evidence map›Paper›PMID 38401537›Full record

ArticleStructure (London, England : 1993)2024

Membrane mimetic-dependence of GPCR energy landscapes.

Naveen Thakur, Arka Prabha Ray, Beining Jin, Nessa Pesaran Afsharian, Edward Lyman, Zhan-Guo Gao, Kenneth A Jacobson, Matthew T Eddy

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Examining the thermotropic properties of large circularized nanodiscs.Biochimica et biophysica acta. Biomembranes · 2025
    Article
  2. Review
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Nanodiscs for the study of membrane proteins.Current opinion in structural biology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Naveen ThakurDepartment of Chemistry, University of Florida, 126 Sisler Hall, Gainesville, FL 32611, USA.
Arka Prabha RayDepartment of Chemistry, University of Florida, 126 Sisler Hall, Gainesville, FL 32611, USA.
Beining JinDepartment of Chemistry, University of Florida, 126 Sisler Hall, Gainesville, FL 32611, USA.
Nessa Pesaran AfsharianDepartment of Chemistry, University of Florida, 126 Sisler Hall, Gainesville, FL 32611, USA.
Edward LymanDepartment of Physics and Astronomy, University of Delaware, Newark, DE, USA.
Zhan-Guo GaoLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Kenneth A JacobsonLaboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Matthew T EddyDepartment of Chemistry, University of Florida, 126 Sisler Hall, Gainesville, FL 32611, USA. Electronic address: matthew.eddy@chem.ufl.edu.

Funding

Development Of Drugs Acting At Adenosine ReceptorsZIADK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$10.4M
Computer Modeling of G Protein-Coupled ReceptorsZIADK031126 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 2009 to 2025
$6.6M
R35 Supplement - Equipment SupplementR35GM138291 · NIGMS · UNIVERSITY OF FLORIDA · PI Matthew Thomas Eddy · 2020 to 2026
$2.5M
Effects of lipidomic diversity on GPCRR01GM120351 · NIGMS · UNIVERSITY OF DELAWARE · PI LYMAN, EDWARD RAY · 2017 to 2021
$1.6M
Drugs that Act at Adenosine ReceptorsZ01DK031117 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI JACOBSON, KENNETH ALAN · 1991 to 2008
$854k
NMR console upgrade for structural biology and metabolomicsS10OD028753 · OD · UNIVERSITY OF FLORIDA · PI LONG, JOANNA R · 2020 to 2020
$600k
Intramural NIH HHS Z01 DK031117Intramural NIH HHS ZIA DK031117NIGMS NIH HHS R01 GM120351NIGMS NIH HHS R35 GM138291NIH HHS S10 OD028753
6 · The paper itself

Abstract

We leveraged variable-temperature

Indexed as

Receptor, Adenosine A2AAdenosine A2 Receptor AgonistsHEK293 CellsHumansModels, MolecularNuclear Magnetic Resonance, BiomolecularProtein BindingProtein ConformationTemperatureAdenosine A2 Receptor AgonistsADORA2A protein, humanReceptor, Adenosine A2AA(2A) adenosine receptorcellular signalingGPCRmembrane mimeticsNMR

Identifiers

PMID38401537
PMCPMC11069452

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.