ArticleAnnals of intensive care2024
Long-stay ICU patients with frailty: mortality and recovery outcomes at 6 months.
Article in Annals of intensive care, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- [Frailty in intensive care medicine].Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2026Pooled it
- Frailty and postoperative complications in elderly patients undergoing cardiac surgery: a systematic review and meta-analysis.BMC geriatrics · 2026Pooled it
- Impact of frailty on outcomes following coronary artery bypass grafting: a systematic review and meta-analysis.BMC surgery · 2024Pooled it
- Eravacycline in Critically Ill Patients with Multidrug-Resistant Gram-Negative Infections: A Real-World Cohort Study.Journal of clinical medicine · 2026Article
- Article
- The association of frailty and mechanical power with hospital mortality in critically ill patients: a retrospective study based on the MIMIC-IV and eICU database.European journal of medical research · 2025Article
- Frailty and Outcomes in Elderly ICU Patients: Insights from a Portuguese Cohort.Healthcare (Basel, Switzerland) · 2025Article
- Evaluation of the clinical frailty scale for predicting mortality or functional dependence at ICU discharge: A cohort study.Scientific reports · 2025Article
- Long-term cardiovascular complications in COVID-19 survivors according to disease severity.Scientific reports · 2025Article
- Review
- A prediction model for 'ICU mortality or prolonged ICU stay' in critically unwell patients with acute pancreatitis: insights from a 2003-2020 cohort analysis using the ANZICS-CORE database.Critical care (London, England) · 2025Article
- The use of mechanical ventilation in interstitial lung disease.Breathe (Sheffield, England) · 2025Review
- The Importance of Frailty in Determining Survival After Intensive Care.Journal of clinical medicine · 2025Article
- Frailty as an independent risk factor for sepsis-associated delirium: a cohort study of 11,740 older adult ICU patients.Aging clinical and experimental research · 2025Article
- Frailty influences clinical outcomes in critical patients: a post hoc analysis of the PalMuSIC study.Critical care science · 2025Article
- Article
- Association between phase angle and daily creatinine excretion changes in critically ill patients: an approach to muscle mass.Frontiers in physiology · 2024Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlonged intensive care unit (ICU) stay is associated with physical, cognitive, and psychological disabilities. The impact of baseline frailty on long-stay ICU patients remains uncertain. This study aims to investigate how baseline frailty influences mortality and post-ICU disability 6 months after critical illness in long-stay ICU patients.
methodsIn this retrospective cohort study, we assessed patients hospitalized for ≥ 7 days in the ICU between May 2018 and May 2021, following them for up to 6 months or until death. Based on the Clinical Frailty Scale (CFS) at ICU admissions, patients were categorized as frail (CFS ≥ 5), pre-frail (CFS 3-4) and non-frail (CFS 1-2). Kaplan-Meier curves and a multivariate Cox model were used to examine the association between frailty and mortality. At the 6 month follow-up, we assessed psychological, physical, cognitive outcomes, and health-related quality of life (QoL) using descriptive statistics and linear regressions.
resultsWe enrolled 531 patients, of which 178 (33.6%) were frail, 200 (37.6%) pre-frail and 153 (28.8%) non-frail. Frail patients were older, had more comorbidities, and greater disease severity at ICU admission. At 6 months, frail patients presented higher mortality rates than pre-frail and non-frail patients (34.3% (61/178) vs. 21% (42/200) vs. 13.1% (20/153) respectively, p < 0.01). The rate of withdrawing or withholding of care did not differ significantly between the groups. Compared with CFS 1-2, the adjusted hazard ratios of death at 6 months were 1.7 (95% CI 0.9-2.9) for CFS 3-4 and 2.9 (95% CI 1.7-4.9) for CFS ≥ 5. At 6 months, 192 patients were seen at a follow-up consultation. In multivariate linear regressions, CFS ≥ 5 was associated with poorer physical health-related QoL, but not with poorer mental health-related QoL, compared with CFS 1-2.
conclusionFrailty is associated with increased mortality and poorer physical health-related QoL in long-stay ICU patients at 6 months. The admission CFS can help inform patients and families about the complexities of survivorship during a prolonged ICU stay.
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