Evidence map›Paper›PMID 38401002›Full record

ArticleMolecular biology reports2024

PXMP4 promotes gastric cancer cell epithelial-mesenchymal transition via the PI3K/AKT signaling pathway.

Wei Li, Xiangyang Dong, Zhidan Wan, Wenxin Wang, Jingyu Zhang, Yongrun Mi, Ruiyuan Li, Zishan Xu, Beixi Wang, Na Li and 1 more

Abstract read
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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Wei LiSchool of forensic Medicine, Xinxiang Medical University, Xinxiang, 453000, China.
Xiangyang DongDepartment of Pathology, Xinxiang Medical University, Xinxiang, 453000, China.
Zhidan WanDepartment of Pathology, Xinxiang Medical University, Xinxiang, 453000, China.
Wenxin WangDepartment of Pathology, Xinxiang Medical University, Xinxiang, 453000, China.
Jingyu ZhangDepartment of Pathology, Xinxiang Medical University, Xinxiang, 453000, China.
Yongrun MiSchool of forensic Medicine, Xinxiang Medical University, Xinxiang, 453000, China.
Ruiyuan LiDepartment of Pathology, Xinxiang Medical University, Xinxiang, 453000, China.
Zishan XuDepartment of Pathology, Xinxiang Medical University, Xinxiang, 453000, China.
Beixi WangThe Fourth Clinical College, Xinxiang Medical University, Xinxiang, 453000, China.
Na LiDepartment of Pathology, Xinxiang Medical University, Xinxiang, 453000, China. yaoyao-lina@163.com.
Guoyang HeDepartment of Pathology, Xinxiang Medical University, Xinxiang, 453000, China. heguoyang529@126.com.ORCID http://orcid.org/0000-0001-6824-4085
Xinxiang Medical University · CN

Funding

National and Henan Province Innovation and Entrepreneurship Training Program for College students of Xinxiang Medical University 202210472052National and Henan Province Innovation and Entrepreneurship Training Program for College students of Xinxiang Medical University 202310472007the key Scientific Research Project of Henan Province Colleges and Universities 23B310002
6 · The paper itself

Abstract

backgroundPeroxisomal membrane protein 4 (PXMP4), a member of the peroxisome membrane protein PXMP2/4 family, participates in the progression of several malignant cancers. Nevertheless, the effect of PXMP4 in the development of gastric cancer (GC) is still unknown. As a result, the focus of this investigation was to elucidate the potential mechanisms of PXMP4 in GC. METHODS AND

resultsFirstly, bioinformatics analysis results showed higher expression of PXMP4 in GC tissues. Secondly, clinical analysis of 57 patients with GC revealed correlations between PXMP4 expression and differentiation, depth of invasion, as well as TNM stage. Furthermore, individuals with elevated PXMP4 expression in GC exhibited an unfavorable prognosis. In vitro data showed the involvement of knockdown/overexpression of PXMP4 in the proliferation, invasion, and migration of GC cells, and triggering the epithelial-mesenchymal transition (EMT) of GC cells through the activation of the PI3K/AKT signaling pathway. LY294002, a PI3K/AKT inhibitor, inhibited the expression of PI3K/AKT-related proteins but did not affect the expression of PXMP4.

conclusionsThese findings indicate that PXMP4 potentially functions as an upstream molecule in the PI3K/AKT pathway, governing the EMT process in GC.

Indexed as

Proto-Oncogene Proteins c-aktStomach NeoplasmsCell Line, TumorCell MovementCell ProliferationEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticHumansMembrane ProteinsPhosphatidylinositol 3-KinasesSignal TransductionMembrane ProteinsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPXMP2 protein, humanEpithelial-mesenchymal transitionGastric cancerPI3K/AKTPXMP4

Identifiers

PMID38401002
OpenAlexW4392131445

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.