Evidence map›Paper›PMID 38400954›Full record

ArticleNeuroradiology2024

Phase-contrast magnetic resonance imaging of intracranial and extracranial blood flow in carotid near-occlusion.

Madelene Holmgren, Alexander Henze, Anders Wåhlin, Anders Eklund, Allan J Fox, Elias Johansson

Open access · hybridAbstract read
In one paragraph

Article in Neuroradiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Madelene HolmgrenDepartment of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden.
Alexander HenzeDepartment of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden.
Anders WåhlinDepartment of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden.
Anders EklundDepartment of Radiation Sciences, Biomedical Engineering, Umeå University, Umeå, Sweden.
Allan J FoxSunnybrook Health Science Center, University of Toronto, Toronto, Canada.
Elias JohanssonDepartment of Clinical Sciences, Neurosciences, Umeå University, Umeå, Sweden. elias.johansson@neuro.gu.se.ORCID http://orcid.org/0000-0001-5317-4563
Umeå University · SESunnybrook Health Science Centre · CAUniversity of Gothenburg · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCompare extracranial internal carotid artery flow rates and intracranial collateral use between conventional ≥ 50% carotid stenosis and carotid near-occlusion, and between symptomatic and asymptomatic carotid near-occlusion.

methodsWe included patients with ≥ 50% carotid stenosis. Degree of stenosis was diagnosed on CTA. Mean blood flow rates were assessed with four-dimensional phase-contrast MRI.

resultsWe included 110 patients of which 83% were symptomatic, and 38% had near-occlusion. Near-occlusions had lower mean internal carotid artery flow (70 ml/min) than conventional ≥ 50% stenoses (203 ml/min, P < .001). Definite use of ≥ 1 collateral was found in 83% (35/42) of near-occlusions and 10% (7/68) of conventional stenoses (P < .001). However, there were no differences in total cerebral blood flow (514 ml/min vs. 519 ml/min, P = .78) or ipsilateral hemispheric blood flow (234 vs. 227 ml/min, P = .52), between near-occlusions and conventional ≥ 50% stenoses, based on phase-contrast MRI flow rates. There were no differences in total cerebral or hemispheric blood flow, or collateral use, between symptomatic and asymptomatic near-occlusions.

conclusionNear-occlusions have lower internal carotid artery flow rates and more collateral use, but similar total cerebral blood flow and hemispheric blood flow, compared to conventional ≥ 50% carotid stenosis.

Indexed as

Carotid Artery DiseasesCarotid StenosisCarotid Artery, InternalCerebrovascular CirculationConstriction, PathologicHumansMagnetic Resonance ImagingCarotid near-occlusionCarotid stenosisCollateralsCT angiographyIntracerebral flowPhase-contrast MRI

Identifiers

PMID38400954
PMCPMC10937755
OpenAlexW4392131313

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.