Evidence map›Paper›PMID 38400939›Full record

ArticleAnalytical and bioanalytical chemistry2024

A new methodology to reveal potential nucleic acid modifications associated with the risk of endometrial cancer through dispersive solid-phase extraction coupled with UHPLC-QE-Orbitrap-MS/MS and HPLC-UV.

Huanhuan Zhao, Xiaoguang Zhang, Lujie Zuo, Li Li, Hongfang Yang, Mengyu Zhang, Na Wang, Qingzhong Jia, Yan Liu

Erratum issuedAbstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Huanhuan Zhao *Department of Obstetrics and Gynecology, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei Province, People's Republic of China.
Xiaoguang Zhang *Core Facilities and Centers, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, People's Republic of China.
Lujie ZuoCollege of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, People's Republic of China.
Li LiDepartment of Obstetrics and Gynecology, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei Province, People's Republic of China.
Hongfang YangDepartment of Medical Laboratory, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei Province, People's Republic of China.
Mengyu ZhangDepartment of Obstetrics and Gynecology, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei Province, People's Republic of China.
Na WangDepartment of Obstetrics and Gynecology, Fourth Hospital of Hebei Medical University, Shijiazhuang, 050011, Hebei Province, People's Republic of China.
Qingzhong JiaCollege of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, People's Republic of China. qizhjia@hebmu.edu.cn.
Yan LiuCollege of Pharmacy, Hebei Medical University, Shijiazhuang, 050017, Hebei Province, People's Republic of China. 18500968@hebmu.edu.cn.
Hebei Medical University · CNFourth Hospital of Hebei Medical University · CN

Funding

Medical Science Foundation of Hebei Provine 20220080Natural Science Foundation of Hebei Province H2022206240the Research Project of Traditional Chinese Medicine Administration of Hebei Province 2023357
6 · The paper itself

Abstract

Nucleic acid modifications have attracted increasing attention in recent years since they have been found to be related to a number of diseases including cancer. Previous studies have shown that the early development of endometrial cancer (EC) is often accompanied by changes in methylation levels of related genes, and the expression of related proteins that regulate reactive oxygen species (ROS) shows significant differences in EC cells and tissues. However, it has not been reported whether nucleic acid modifications related to methylation or ROS can serve as biomarkers for EC. Accurate quantification of these nucleic acid modifications still has challenges because their amounts in urine are very low and the interferences in urine are complicated. In this study, a novel dispersive solid-phase extraction (DSPE) method based on chitosan-carbon nanotube-Al

Indexed as

Endometrial NeoplasmsNucleic Acids8-Hydroxy-2'-DeoxyguanosineBiomarkersChromatography, High Pressure LiquidFemaleHumansReactive Oxygen SpeciesSolid Phase ExtractionTandem Mass Spectrometry8-Hydroxy-2'-DeoxyguanosineBiomarkersNucleic AcidsReactive Oxygen SpeciesBiomarkerCS-CNT-Al2O3Dispersive solid-phase extractionEndometrial cancerNucleic acid modifications

Identifiers

PMID38400939
OpenAlexW4392128515

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.