Evidence map›Paper›PMID 38400867›Full record

ArticleMolecular biology reports2024

Exploring miR-155-5p and miR-1246 as Diagnostic and Prognostic Markers in Oral Squamous cell carcinoma.

R Maheswari, Aadithya B Urs, Priya Kumar, B C Koner, Sameer Ahmad Guru, Garima Rawat

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Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. The potential role of miR-155 in the tumorigenesis of cervical cancer.Frontiers in cell and developmental biology · 2025
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

R MaheswariDepartment of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India.
Aadithya B UrsDepartment of Oral Pathology, Maulana Azad Institute of Dental Sciences, New Delhi, 110002, India.
Priya KumarDepartment of Oral Pathology, Maulana Azad Institute of Dental Sciences, MAMC Complex, Mirdard Marg, Bahadur Shah Zafar Marg, LNJP Colony, New Delhi, 110002, India. drpri_kumar@yahoo.com.ORCID https://orcid.org/0000-0003-0535-8098
B C KonerDepartment of Biochemistry, Maulana Azad Medical College, New Delhi, 110002, India.
Sameer Ahmad GuruDevelopmental Systems Biology, Ann and Lurie Children's Hospital, Northwestern University, Chicago, IL, 60611, USA.
Garima RawatDepartment of Pathology, Dharamshila Narayana Superspeciality Hospital, New Delhi, 110002, India.
Maulana Azad Institute of Dental Sciences · INMaulana Azad Medical College · INNethradhama Superspeciality Eye Hospital · INNorthwestern University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOral Squamous Cell Carcinoma (OSCC) is one of the leading cancers worldwide, significantly impacting developing nations. This study aimed to explore the diagnostic and prognostic potential of miR-155-5p and miR-1246 in OSCC in the Indian population, as their comparative roles in this context remain unexplored. MATERIAL AND

methodsThe present cross-sectional study comprised 50 histopathologically confirmed OSCC cases, with adjacent normal mucosa as controls. MiRNA expression was assessed via qRT-PCR and correlated with clinicopathological factors. MiRwalk and miRTargetlink were used for miRNA:mRNA interaction prediction, and gprofiler was employed to analyze validated targets for functional insights.

resultsThe expression analysis showed a significant upregulation of miR-155-5p and miR-1246 in OSCC tissues compared to adjacent controls. Receiver operating curve analysis revealed that miR-1246 exhibited excellent diagnostic accuracy (AUC = 0.94) compared to miR-155-5p (AUC = 0.69). Higher miRNA levels were associated with age and extracapsular extension while overexpression of miR-1246 was correlated significantly with increased tumor size, tumor grade, TNM staging, and depth of invasion. The analysis for target prediction unveiled a set of validated targets, among which were WNT5A, TP53INP1, STAT3, CTNNB1, PRKAR1A, and NFIB.

conclusionmiR-155-5p and miR-1246 may be used as potential prognostic biomarkers in OSCC, with miR-1246 demonstrating superior diagnostic accuracy.

Indexed as

Carcinoma, Squamous CellHead and Neck NeoplasmsMicroRNAsMouth NeoplasmsCarrier ProteinsCell Line, TumorCell MovementCell ProliferationCross-Sectional StudiesGene Expression Regulation, NeoplasticHeat-Shock ProteinsHumansPrognosisSquamous Cell Carcinoma of Head and NeckCarrier ProteinsHeat-Shock ProteinsMicroRNAsMIRN1246 microRNA, humanMIRN155 microRNA, humanTP53INP1 protein, humanApoptosisCancer stemnessHead and neck cancermiRNA (miR)–1246miRNA (miR)–155Oral squamous cell carcinoma (OSCC)

Identifiers

PMID38400867
OpenAlexW4392132056

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.