Evidence map›Paper›PMID 38400665›Full record

ArticleCancer medicine2024

Cocaine use and head and neck cancer risk: A pooled analysis in the International Head and Neck Cancer Epidemiology Consortium.

Mingyan Zhang, Chu Chen, Guojun Li, Alzina Koric, Yuan-Chin Amy Lee, Hal Morgenstern, Stephen M Schwartz, Erich M Sturgis, Paolo Boffetta, Mia Hashibe and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Mingyan ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.ORCID 0000-0002-7602-504X
Chu ChenProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Guojun LiDepartment of Head and Neck Surgery, Division of Surgery, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Alzina KoricDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Yuan-Chin Amy LeeDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Hal MorgensternDepartments of Epidemiology and Environmental Health Sciences, School of Public Health and Department of Urology, Medical School, University of Michigan, Ann Arbor, Michigan, USA.
Stephen M SchwartzProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Erich M SturgisDepartment of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine, Houston, Texas, USA.
Paolo BoffettaStony Brook Cancer Center, Department of Family, Population and Preventive Medicine, Stony Brook University, Stony Brook, New York, USA.
Mia HashibeDivision of Public Health, Department of Family and Preventive Medicine, University of Utah School of Medicine, and Huntsman Cancer Institute, Salt Lake City, Utah, USA.
Zuo-Feng ZhangDepartment of Epidemiology, UCLA Fielding School of Public Health, Los Angeles, California, USA.
University of Utah · USFred Hutch Cancer Center · USUCLA Health · USBaylor College of Medicine · USStony Brook University · USThe University of Texas MD Anderson Cancer Center · USUniversity of Michigan · US

Funding

UCLA SPORE IN LUNG CANCERP50CA090388 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2001 to 2008
$13.0M
UCLA CANCER EPIDEMIOLOGY TRAINING PROGRAMT32CA009142 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1986 to 2024
$6.3M
Molecular Epidemiology of Head and Neck CancerR01ES011740 · NIEHS · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2001 to 2012
$6.3M
LUNG CANCER CHEMOPREVENTION WITH CELECOXIB IN EX-SMOKERSU01CA096134 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MAO, JENNY T · 2002 to 2007
$5.1M
MARIJUANA USE AND THE RISKS OF LUNG AND OTHER CANCERSR01DA011386 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MORGENSTERN, HAL M · 1999 to 2003
$1.8M
Genetic Predictors for DNA Repair Phenotype in CMMR01CA100264 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI WEI, QINGYI · 2004 to 2008
$1.5M
Molecular Epidemiology and Gene-Environment InteractionR21ES011667 · NIEHS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 2002 to 2004
$651k
ORAL CANCER--DNA POLYMORPHISMS IN CARCINOGEN METABOLISMR01DE012609 · NIDCR · FRED HUTCHINSON CANCER RESEARCH CENTER · PI SCHWARTZ, STEPHEN MARC · 1998 to 2001
$415k
HELICOBACTER PYLORI MALNUTRITION AND GASTRIC CANCERR03CA077954 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ZHANG, ZUO-FENG · 1997 to 1998
–
NCI NIH HHS CA009142NCI NIH HHS P50 CA090388NCI NIH HHS R01 CA048896NCI NIH HHS R01 CA100264NCI NIH HHS R03 CA077954NCI NIH HHS T32 CA009142NCI NIH HHS U01 CA096134NIDA NIH HHS DA011386NIDA NIH HHS R01 DA011386NIDCR NIH HHS R01 DE012609NIEHS NIH HHS ES006718NIEHS NIH HHS ES011667NIEHS NIH HHS R01 ES011740NIEHS NIH HHS R21 ES011667NIH HHS CA009142NIH HHS CA090388NIH HHS CA096134NIH HHS DA011386NIH HHS ES011667NIH HHS R01CA048896NIH HHS R01CA100264NIH HHS R01DE012609NIH HHS R01ES011740
6 · The paper itself

Abstract

backgroundCocaine is an illegal recreational drug used worldwide, yet little is known about whether cocaine inhalation (smoking/snorting) increases the risk of head and neck cancer (HNC).

methodsThe analyses were conducted by pooling data from three case-control studies with 1639 cases and 2506 controls from the International Head and Neck Cancer Epidemiology Consortium. Epidemiologic data, including cocaine use histories, were obtained in face-to-face interviews. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using hierarchical logistic regression models.

resultsControlling for cumulative tobacco and alcohol use, we observed a weak positive association between cocaine use and HNC (OR

conclusionIn this pooled analysis, we observed a weak positive association between cocaine inhalation and HNC risk. Our findings provide preliminary evidence of the potential carcinogenic effect of cocaine on HNC. Because of study limitations, including limited number of cocaine users, confounding, and heterogeneity across studies, future investigations will require larger studies with more detailed information on cocaine use history.

Indexed as

CocaineHead and Neck NeoplasmsAlcohol DrinkingCase-Control StudiesHumansRisk FactorsSmokingCocainecancer preventioncocaine inhalationdrug usehead and neck cancer

Identifiers

PMID38400665
PMCPMC10891447
OpenAlexW4392137315

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.