Evidence map›Paper›PMID 38400528›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024

Patient- and proxy-reported quality of life in advanced dementia with Lewy bodies.

Melissa J Armstrong, Brian LaBarre, Kaitlin Sovich, Susan M Maixner, Henry L Paulson, Carol Manning, Julie A Fields, Angela Lunde, Leah Forsberg, Bradley F Boeve and 3 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Behavioral disorders in dementia with Lewy bodies: old and new knowledge.Journal of neural transmission (Vienna, Austria : 1996) · 2025
    Review
  5. Article
  6. Patient- and proxy-reported quality of life in advanced dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Melissa J ArmstrongDepartment of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA.
Brian LaBarreDepartment of Biostatistics, University of Florida College of Medicine, Gainesville, Florida, USA.
Kaitlin SovichDepartment of Neurology, University of Florida College of Medicine, Gainesville, Florida, USA.
Susan M MaixnerDepartment of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA.
Henry L PaulsonDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USA.
Carol ManningDepartment of Neurology, University of Virginia, Charlottesville, Virginia, USA.
Julie A FieldsDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota, USA.
Angela LundeDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Leah ForsbergDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
James E GalvinComprehensive Center for Brain Health, Department of Neurology, University of Miami Miller School of Medicine, Miami, Florida, USA.
Angela S TaylorLewy Body Dementia Association, Lilburn, Georgia, USA.
Zhigang LiDepartment of Biostatistics, University of Florida College of Medicine, Gainesville, Florida, USA.
Mayo Clinic · USFlorida College · USUniversity of Florida · USUniversity of Michigan–Ann Arbor · USDementia UK · GBUniversity of Miami Health System · USUniversity of Virginia · US

Funding

Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI Pamela J McLean · 2019 to 2026
$33.5M
A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Phase 2 Study to Evaluate the Safety and Efficacy of CT1812 in Subjects with Dementia with Lewy BodiesR01AG071643 · NIA · COGNITION THERAPEUTICS, INC. · PI CAGGIANO, ANTHONY O, GALVIN, JAMES E · 2021 to 2023
$29.5M
Social Determinants of Health, Race/Ethnicity, and White Matter HyperintensitiesP30AG066506 · NIA · UNIVERSITY OF FLORIDA · PI Rosie E Curiel Cid · 2020 to 2026
$25.6M
Longitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2M
Research Methods CoreP01AG066584 · NIA · WASHINGTON STATE UNIVERSITY · PI KA'IMI ALOHILANI SINCLAIR · 2021 to 2026
$17.4M
Multicultural Community Dementia ScreeningR01AG071514 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2021 to 2025
$13.8M
Changing the Trajectory of Mild Cognitive Impairment with CPAP Treatment of Obstructive Sleep ApneaR01AG054435 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GOONERATNE, NALAKA S, WOLK, DAVID A · 2017 to 2020
$10.3M
Michigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALBIN, ROGER L · 2016 to 2020
$10.1M
Reducing Disparities in Dementia and VCID Outcomes in a Multicultural Rural PopulationR01NS101483 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI GALVIN, JAMES E · 2019 to 2023
$8.0M
University of Florida - Mt. Sinai Medical Center AD Research CenterP50AG047266 · NIA · UNIVERSITY OF FLORIDA · PI LOEWENSTEIN, DAVID · 2015 to 2019
$7.3M
The LUCINDA TrialR01AG057681 · NIA · WEILL MEDICAL COLL OF CORNELL UNIV · PI ATWOOD, CRAIG S, BUTLER, TRACY A. · 2018 to 2024
$7.2M
Slow wave sleep (SWS) and the effect of African ancestry on amyloid burden, a longitudinal studyR01AG056531 · NIA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI JEAN-LOUIS, GIRARDIN, OSORIO, RICARDO S · 2018 to 2022
$6.7M
NIA NIH HHS P01 AG066584NIA NIH HHS P30 AG047266NIA NIH HHS P30 AG053760NIA NIH HHS P30 AG059295NIA NIH HHS P30 AG062677NIA NIH HHS P30 AG066506NIA NIH HHS R01 AG054435NIA NIH HHS R01 AG056531NIA NIH HHS R01 AG057681NIA NIH HHS R01 AG068128NIA NIH HHS R01 AG069765NIA NIH HHS R01 AG071514NIA NIH HHS R01 AG071643NIA NIH HHS R01 AG078214NIA NIH HHS R43 AG065088NIA NIH HHS R44 AG062072NIA NIH HHS R56 AG074889NIA NIH HHS RF1 AG075901NIA NIH HHS SB1 AG037357NIGMS NIH HHS S06 GM142115NINDS NIH HHS R01 NS101483NINDS NIH HHS R01 NS121099NINDS NIH HHS U01 NS100620
6 · The paper itself

Abstract

introductionLittle is known regarding quality of life (QoL) in dementia with Lewy bodies (DLB), particularly in advanced stages.

methodsDyads of individuals with moderate-advanced DLB and their primary caregivers were recruited from specialty clinics, advocacy organizations, and research registries. The study collected demographics, disease-related measures, and measures of patient/caregiver experiences.

resultsThe Quality of Life in Alzheimer's Disease (QoL-AD) was completed by the person with DLB and the caregiver (proxy) in 61 dyads; 85 dyads had only a proxy-completed QoL-AD. Patient- and proxy-reported scores were moderately correlated (r = 0.57, P < 0.0001). Worse patient-reported QoL correlated with daytime sleepiness, autonomic symptom burden, and behavioral symptoms. Proxy ratings correlated with dementia severity, daytime sleepiness, behavioral symptoms, dependence in activities of daily living, and caregiver experience measures. DISCUSSION: Patient- and proxy-reported quality of life (QoL) should be assessed separately in advanced DLB. Some symptoms associated with QoL have available therapeutic options. Research is needed regarding strategies to optimally improve QoL in DLB. HIGHLIGHTS: Patient and proxy quality of life (QoL) ratings had moderate correlation in advanced dementia with Lewy bodies. Daytime sleepiness affected patient- and proxy-reported QoL. Behavioral symptoms affected patient- and proxy-reported QoL. Autonomic symptom burden affected patient-reported QoL. Dementia severity, dependence, and caregiver experiences affected proxy ratings.

Indexed as

Alzheimer DiseaseDisorders of Excessive SomnolenceLewy Body DiseaseActivities of Daily LivingCaregiversHumansQuality of Lifecaregiversdementiadementia with Lewy bodiesLewy body diseasequality of life

Identifiers

PMID38400528
PMCPMC11032544
OpenAlexW4392132145

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.