ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2024
Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Trial
- Multimorbidity, Polypharmacy, and Neighborhood Disadvantage as Determinants of Cognitive Performance in the ARCHES Cohort.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026Article
- Probing effect modification by socioeconomic status in associations between blood biomarkers of neuropathology and cognitive outcomes in the United States and India.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Theoretical and practical challenges for capturing reserve and resilience in aging and Alzheimer's disease: A narrative review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Association Between ICD-Coded Delirium and Health Determinants in The Atherosclerosis Risk in Communities Study.Journal of the American Geriatrics Society · 2026Article
- Social determinants of brain structure and cognition.Social science & medicine (1982) · 2026Article
- Association of residential neighborhood disadvantage with amyloid PET positivity among cognitively impaired individuals.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2026Article
- Association of neighborhood disadvantage with Alzheimer's disease pathology and the stability of blood-based biomarker performance.The journal of prevention of Alzheimer's disease · 2026Observational
- Neighborhood socioeconomic deprivation is associated with worse cognitive performance and in vivo amyloid accumulation.NPJ dementia · 2026Article
- Educational attainment and sex modulate clinical outcomes in genetic frontotemporal dementia.Brain communications · 2026Article
- Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Neighborhood disadvantage and subjective cognitive function among older Black women.Psychology and aging · 2025Article
- The Neighborhoods Study: Examining the social exposome in Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration.medRxiv : the preprint server for health sciences · 2025Article
- Neighborhood-level socioeconomic disadvantage is associated with multiple cognitive domains in a community sample of older adults.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2025Article
- Cognitive maintenance in older adults in social classes: a secondary analysis of the longitudinal SHARE data.Journal of epidemiology and community health · 2025Article
- Identifying longitudinal cognitive resilience from cross-sectional amyloid, tau, and neurodegeneration.Alzheimer's research & therapy · 2024Article
- Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Impact of neighborhood disadvantage on cardiometabolic health and cognition in a community-dwelling cohort.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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9 authors.
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Abstract
introductionIndividuals in socioeconomically disadvantaged neighborhoods exhibit increased risk for impaired cognitive function. Whether this association relates to the major dementia-related neuropathologies is unknown.
methodsThis cross-sectional study included 469 autopsy cases from 2011 to 2023. The relationships between neighborhood disadvantage measured by Area Deprivation Index (ADI) percentiles categorized into tertiles, cognition evaluated by the last Mini-Mental State Examination (MMSE) scores before death, and 10 dementia-associated proteinopathies and cerebrovascular disease were assessed using regression analyses.
resultsHigher ADI was significantly associated with lower MMSE score. This was mitigated by increasing years of education. ADI was not associated with an increase in dementia-associated neuropathologic change. Moreover, the significant association between ADI and cognition remained even after controlling for changes in major dementia-associated proteinopathies or cerebrovascular disease. DISCUSSION: Neighborhood disadvantage appears to be associated with decreased cognitive reserve. This association is modified by education but is independent of the major dementia-associated neuropathologies.
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