Evidence map›Paper›PMID 38400153›Full record

ArticleVaccines2024

Intussusception and Other Adverse Event Surveillance after Pilot Introduction of Rotavirus Vaccine in Nam Dinh and Thua Thien Hue Provinces-Vietnam, 2017-2021.

Ly Khanh Thi Le, Thao Phuong Thi Pham, Le Thi Phuong Mai, Quyet Tu Nguyen, Mai Phuong Ngoc Tran, Thien Huu Ho, Hung Hoang Pham, Sanh Van Le, Ha Ngoc Hoang, Anh Tuan Lai and 7 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 2 countries.

Ly Khanh Thi LeNational Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
Thao Phuong Thi PhamCenter for Research and Production of Vaccines and Biologicals, Hanoi 100000, Vietnam.ORCID 0009-0006-6860-9252
Le Thi Phuong MaiNational Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.ORCID 0000-0001-7581-4058
Quyet Tu NguyenNational Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
Mai Phuong Ngoc TranNational Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
Thien Huu HoCentral Hue Hospital, Thua Thien Hue 530000, Vietnam.
Hung Hoang PhamCentral Hue Hospital, Thua Thien Hue 530000, Vietnam.
Sanh Van LeHue Center for Disease Control, Thua Thien Hue 530000, Vietnam.
Ha Ngoc HoangNam Dinh General Hospital, Nam Dinh 420000, Vietnam.
Anh Tuan LaiNam Dinh Center for Disease Control, Nam Dinh 420000, Vietnam.
Nguyen Thuy HuongCenter for Research and Production of Vaccines and Biologicals, Hanoi 100000, Vietnam.
Hien Dang NguyenCenter for Research and Production of Vaccines and Biologicals, Hanoi 100000, Vietnam.
Dang Duc AnhNational Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
Makiko IijimaWorld Health Organization, Vietnam Office, Hanoi 100000, Vietnam.
Umesh D ParasharUnited States Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Nguyen Van TrangNational Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam.
Jacqueline E TateUnited States Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
National Institute Of Hygiene And Epidemiology · VNHue Central Hospital · VNNational Institute for Control of Vaccines and Biologicals · VNCenters for Disease Control and Prevention · USNam Dinh University of Nursing · VN

Funding

Gates Foundation INV-010668World Health Organization 001
6 · The paper itself

Abstract

Rotavin-M1 (POLYVAC) was licensed in Vietnam in 2012. The association of Rotavin-M1 with intussusception, a rare adverse event associated with rotavirus vaccines, and with adverse events following immunization (AEFI) have not been evaluated and monitored under conditions of routine use. From February 2017 to May 2021, we conducted a pilot introduction of Rotavin-M1 into the routine vaccination program in two provinces. Surveillance for intussusception was conducted at six sentinel hospitals. AEFI reports at 30 min and 7 days after vaccination were recorded. Among 443 children <12 months of age admitted for intussusception, most (92.3%) were children ≥ 6 months. Of the 388 children who were age-eligible to receive Rotavin-M1, 116 (29.9%) had received ≥1 dose. No intussusception cases occurred in the 1-21 days after dose 1 and one case occurred on day 21 after dose 2. Among the 45,367 children who received ≥1 dose of Rotavin-M1, 9.5% of children reported at least one AEFI after dose 1 and 7.3% after dose 2. Significantly higher AEFI rates occurred among children given Rotavin-M1 with pentavalent vaccines (Quinvaxem

Indexed as

adverse events following immunization (AEFI)intussusceptionRotavin-M1 vaccinerotavirussafety

Identifiers

PMID38400153
PMCPMC10893515
OpenAlexW4391630486

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.